Ali VERAL, Deniz NART, Ali Rıza KANDİLOĞLU, Semin AYHAN, Peyker TÜRKDOĞAN, Saliha SOYDAN

Nazofarinks karsinomları 186 olgunun histopatolojik incelemesi

Bu çalışmada 186 nazofarinks karsinomu olgusunun histopatolojik özellikleri ve demografik verileri incelenmiştir. Olgularda E/K oranı 1.8/1 olarak saptanmıştır. Olguların 13'ü (%6.9) skuamöz hücreli karsinom, 37'si (%19.9) diferansiye non-keratinize karsinom ve 136'sı (%73.2) indiferan karsinom tanısı almıştır. İndiferan karsinom olgularının oranı literatüre göre yüksektir. 20 olgumuz (%10.7) 20 yaşın altındadır ve bu oran diğer ülkelere göre daha yüksektir. Olgularda yaş ortalaması 46.8 dır. İndiferan karsinomlarda yaş ortalaması diğer gruplara göre daha düşüktür.

Anahtar Kelimeler:

Demografi, Karsinom, yassı hücreli, Geriyedönük çalışma, Yaş faktörü, Nazofaringeal neoplazmlar

Carcinoma of nasopharynx histopathologic examination of 186 cases

In this study we examined histopathological features and demographic data of 186 cases of Nasopharyngeal carcinoma. The M/F ratio was 1.8/1. 13 cases (6.9%) were squamous cell carcinoma, 37 (19.9%) were non-keratinizing carcinoma and 136 (73.2%) were undifferentiated carcinoma. The ratio of undifferentiated carcinoma cases was higher than the same cases in the literature. 20 of our cases (10.7%). were younger than age of 20. This ratio was higher than the other countries. The average age was 46.8. The average age of cases of undifferentiated carcinoma was lower than the other groups.

Keywords:

Demography, Carcinoma, Squamous Cell, Retrospective Studies, Age Factors, Nasopharyngeal Neoplasms,

PDF

___

1. Taxy JB. Upper Respiratory Tract. Damjanov I, Linder J, ed. Anderson's Pathology. 10uncu baskı. St Louis: Mosby, 1990: 1446- 1469.
2. Neel HB III. Nasopharyngeal carcinoma: diagnosis, staging and management. Oncology, 1992; 6:87-95.
3. Feng P, Ren EC, Liu D, Chan SH, Hu H. Expression of epstein-barr virüs lytic gene BRLF1 in nasopharyngeal carcinoma: potential use in diagnosis. J Gen Virol 2000; 81 10:2417-2423.
4. Shanmugaratnam K, Sobin LH. The World Health Organization histological classification of tumours of the upper respiratory tract and ear. Cancer 1993; 71: 2689-2697.
5. Applebaum EL, Mantravidi P, Haas R. Lymphoepithelioma of the nasopharynx. Laryngoscope 1982; 92:510-514.
6. Soydan S, Çoruh G, Arslan A, Ak H. Nazofarinks karsinomu (Erzurum bölgesinde saptanan 33 olgunun incelenmesi). E.Ü. Tıp Fakültesi Dergisi 1984; 23(3):1053-1062.
7. Soydan S, Postacı H, Özdemir N. Nazofarinksin malign epitelial tümörleri. VI. Ulusal Patoloji Kongresi Kitabı: 1984; 131-136.
8. Dickson Rl. Nasopharyngeal carcinoma: An evaluation of 209 patients. Laryngoscope 1981; 92:333-354.
9. Easton JM, Levine PH, Hyams VJ. Nasopharyngeal carcinoma in the United States: A pathologic study of 177 US and 30 foreign cases. Arch Otolaryngol 1980; 106:88-91.
10. Shanmugaratnam K, Sobin LH. Histologic typing of upper respiratory tract tumors, No 19, International histological classification of tumors, Geneva, 1978, WHO:32-33.
11. Shanmugaratnam K, Chan SH, De-The et al. Histopathology of nasopharyngeal carcinoma: Correlations with epidemiology, survival rates and other biological characteristics. Cancer 1974; 44:1029-1046.