Mide karsinoid tümörleri

Mide karsinoid tümörleri nadir görülür ancak sıklığı artmaktadır. Mide karsinoid tümörler enterokromaffin benzeri hücrelerden köken alırlar. Klinik görünümü genellikle nonspesifikdir. Üç tip mide karsinoid tümörü tanımlanmıştır. Tip 1 ve 2 mide karsinoid tümörler hipergastrinemi ile ilişkilidir ve genellikle düşük metastaz potansiyeline sahiptirler. Tip III mide karsinoid tümörler hipergastrinemi ile ilişkisizdir ve yüksek metastaz potansiyeline sahiptirler. Tip 1 ve 2 mide karsinoid tümörler çoğunlukla multifokaldir, ancak tip 3 tümörler genellikle soliter tümörlerdir. Mide karsinoid tümörün gelişiminden gastrin, genetik faktörler, büyüme faktörleri ve matriks regülasyon proteinleri gibi birçok faktör sorumlu tutulmuştur. Biz bu derlemede mide karsinoid tümörlerinin kliniği ve patofizyolojisine odaklanarak, tanı ve tedavileri konusunda son yıllarda sağlanan gelismeleri özetledik.

Gastric carcinoid tumours

Gastric carcinoid tumours are rare, but are increasing in occurence. Gastric carcinoid tumors originate from enterochromaffin-like cells. The clinical presentation is often non-specific. Three subtypes of gastric carcinoid tumors were defined. Types 1 and 2 gastric carcinoid tumours are associated with hypergastrinaemia and usually have low metastatic potential. Type 3 gastric carcinoid tumours are not associated with hypergastrinaemia and have a higher potential for metastatic disease. Most of types 1 and 2 gastric carcinoid tumors are multifocal, however type 3 gastric tumors are often solitary tumors. The development of a gastric carcinoid tumor has been responsible for many factors such as gastrin, genetic factors growth factors and matrix regulating proteins. This review will focus on clinical and pathophysiological facets of gastric carcinoid tumours, summarizing recent data on their diagnosis and management.

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