Amaç: Ege Üniversitesi Hastanesinde 1992-2017 arası kanser tanı ve tedavisi yapılan 3179 kemik ve yumuĢak doku sarkomunun epidemiyolojik ve sağ kalım özelliklerinin analizi ve sonuçların kaynaklarla karĢılaĢtırılmasıdır. Gereç ve Yöntem: Ege Üniversitesi Kanserle SavaĢ AraĢtırma ve Uygulama Merkezi tarafından toplanan kemik ve yumuĢak doku sarkomu verileri CANREG özel bilgisayar programına kayıt edilmiĢ, DSÖ ve SEER sistemleri temelinde gruplanarak analizler yapılmıĢtır. Ġstatistik analizlerde Ki-kare, General Linear Model, Kaplan Meier sağ kalım analizleri uygulanmıĢtır. Kaplan Meier sağ kalım analizinde Log Rank (Mantel-Cox), Breslow (Generalized Wilcoxon) ve Tarone-Ware istatistikleri kullanılmıĢtır. Ġstatistik analizlerde p
Aim: To analyze the epidemiologic, and survival characteristics of 3179 bone and soft tissue sarcomas that were diagnosed as cancer and were treated in Ege University Hospital between 1992 and 2017, and compare the results with resources. Materials and Methods: The data of the bone, and soft tissue sarcomas collected in Ege University Cancer Research Center were recorded in the CANREG special computer program, and the analyses were performed after grouping in the basis of the WHO, and SEER systems. The Chi-square, General Linear Model, Kaplan Meier survival analyses were performed in statistical analyses. Log Rank (Mantel-Cox), Breslow (Generalized Wilcoxon), and Tarone-Ware statistics were used in Kaplan Meier survival analysis. p
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1. Weiss, S.; Goldblum, J. General considerations. In: Weiss, S.; Goldblum, J., editors. Enzinger and Weiss’s Soft Tissue Tumors. St Louis, Missouri: CV Mosby, 2001: 1-19.
2. Unni KK, Inwards CY. Dahlin’s Bone Tumors, 6th ed. Philadelphia: Wolters Kluwer, Lippincott Williams & Wilkins, 2010.
3. Greenspan A, Jundt G, Remagen W. Differential diagnosis in orthopeadic oncology. 2 nd ed. Philadelphia: Lippincott Williams & Wilkins, 2007.
4. Fuchs B, Ossendorf C, Leerapun T, Sim FH: Intercalary segmental reconstruction after bone tumor resection. EJSO 2008; 34 (12): 1271-6.
5. Mathew R, Di Caprio MD, Gary E, Friedlaender MD: Malign bone tumors; Limb sparing versus amputations. Journal of the American Academiy of Orthopaedic Surgeons 2003; 11: 25-37.
6. Picci P. Osteosarcoma (osteogenic sarcoma). Orphanet J Rare Dis 2007; 2: 6.
7. Böhm P, Fritz J, Thiede S, Budach W: Reimplantation of extracorporeal irradiated bone segments in musculoskeletal tumor surgery: clinical experience in eight patients and review of the literature. Langenbecks Arch Surg 2003; 387: 355-65.
8. Trautmanna F, Schulerb M, Schmitta J. Burden of soft-tissue and bone sarcoma in routine care Estimation of incidence, prevalence and survival for health services research. Cancer Epidemiology 2015; 39: 440-6.
9. Stiller CA, Trama A, Serraino D, Rossi S, Navarro C, Chirlaque MD, et al. Descriptive epidemiology of sarcomas in Europe: report from the RARECARE project. Eur J Cancer 2013; 49 (3): 684–95.
10.C.D.M. Fletcher. WHO Classification of Tumours of Soft Tissue and Bone. IARC. 4th Ed. 2013: 240-2.
11.Wibmer C, Leithner A, Zielonke N, Sperl M, Windhager R. Increasing incidence rates of soft tissue sarcomas? A population-based epidemiologic study and literature review. Annals of Oncology 2010; 21: 1106–11.
12.Murphey MD, Walker EA, Wilson AJ, Kransdorf MJ, Temple HT, Gannon FH. From the archives of the AFIP: imagining of primary chondrosarcoma: radiologic-pathologic correlation. Radiographics. 2003; 23 (5): 1245-78.
13.Weis SW, Goldblum JR. Soft Tissue Tumors. 5th. Ed. Mosby, 2008.
14.Cotterill SJ, Ahrens S, Paulussen M, Jurgens HF, Voute PA, et al. Prognostic factors in Ewing’s tumor of bone: Analysis of 975 patients from the European Ġntergroup Cooperative Ewing’s sarcoma Study Group. J of Clinical Oncology 2000; 18 (3): 108-14.