Jeneralize verrü tedavisinde sistemik interferon alfa - 2a: bir olgu sunumu

Deri ve müköz membranları etkileyen human papilloma virus (HPV) enfeksiyonları tüm dünyada oldukça yaygın olarak görülmektedir. Bu enfeksiyonlar benign veya malign tümörlere neden olabilmesi nedeniyle önemlidirler. Kırk dokuz yasında kadın hasta kliniğimize vücudunda, yüzünde ve ağız içinde otuz yıldan beri mevcut olan siğiller nedeni ile basvurdu. Hastanın özgeçmisinde ve soygeçmisinde özellik saptanmadı. Dermatolojik muayenesinde, her iki el dorsumunda, ayak bileğinde, yüz ve anogenital bölgede çok sayıda açık kahverenkte yer yer plan yer yer verrüköz lezyo nlar saptandı. Oral bakıda dil üzerinde ve bukkal mukozada verrüköz papüller izlendi. Daha önce koterizasyon ve eksizyon tedavileri uygulanan ve cevap alınamayan olguya, lezyonlarının yaygın olması nedeniyle, subkutan olarak haftada 3 gün, 3 milyon ünite interferon alfa-2a tedavisi baslandı ve 12 hafta devam edildi. Hastanın ayak bileğindeki ve el dorsal yüzdeki lezyonlarında kısmi gerileme izlendi; diğer lezyonlarında ise değisiklik saptanmadı. Sistemik interferon tedavisi, kondiloma akkümünata, anogenital kanser, laringeal papilloma ve verrü gibi HPV enfeksiyonu ile iliskili hastalıkların tedavisinde kullanılabilmektedir. Burada, jeneralize verrüleri için ĐFN uygulanan bir olgu sunulmakta ve konu literatür bilgileri ısığında tartısılmaktadır.

Anahtar Kelimeler:

Tedavi başarısızlığı, Siğiller, Papillomavirus enfeksiyonları

Systemic interferon alpha - 2a in generalized verruca therapy: a case report

Human papilloma virus infections (HPV) which involve skin and mucous membranes are widespread all over the world. These infections are important because they can lead to benign and malign tumors. 49-year-old woman with persistant warty skin lesions was admitted to our clinic with thirty years history. Her past medical history and family history was unremarkable. On dermatological examination, verrucous plana papules and plaques were observed on the ankles, dorsal surfaces of hands, face and anogenital areas. Also there were verrucous papules on buccal mucosa and tongue. Some lesions had been treated by surgery and cryotherapy without any response. Treatment with interferon alpha-2a was initiated with the dose of subcutaneously 3 million IU , 3 times per week for 12 weeks. Despite the lesions on the ankles and dorsal surfaces of the hands responded to the therapy partially, no response was observed in the other lesions. Systemic interferons can be used to treat condyloma accuminatum, anogenital cancer, laryngeal papilloma and skin warts which are related HPV infection. In this article, a case of generalized verru that was treated with interferon alpha-2a is presented and discussed in the view of the literature.

Keywords:

Treatment Failure, Warts, Papillomavirus Infections,

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