S. HACIVELİOĞLU, M. GENCER, A. N. ÇAKIR GÜNGÖR, A. UYSAL, E. COŞAR

İntraüterin inseminasyon uygulanan hastalarda r-FSH ve klomifen sitrat ile ovülasyon indüksiyon sonuçlarının karşılaştırılması: 130 siklusun analizi

Amaç: İntraüterin inseminasyon (İUİ) uygulanan hastalarda ideal ovülasyon indüksiyon (Oİ) protokolünün hangisi olduğu henüz net olarak bilinmemektedir. Bu retrospektif çalışmanın amacı, İUİ yapılan hastalarda Oİ için kullanılan rekombinan FSH (r-FSH) ve klomifen sitrat (KS)'ın gebelik oranları üzerindeki etkilerini ortaya koymaktır. Gereç ve Yöntem: Taze eş spermi ile İUİ uygulanan 130 siklus retrospektif olarak değerlendirildi. Çalışma iki tedavi grubundan oluştu; birinci gruba r-FSH + İUİ yapılan 35 tedavi siklusu ve ikinci gruba KS+İUİ yapılan 95 tedavi siklusu dahil edildi. Bu iki grup çeşitli klinik ve laboratuar parametreler yönünden karşılaştırıldı. Bulgular: Gebelik oranı r-FSH grubunda %17,1 ve KS grubunda %10,5 olarak saptandı ve aralarında istatistiksel fark bulunmadı (p=0,368). hCG günündeki endometrium (EM), KS grubunda daha ince izlendi (p

Comparison of the outcome between cycles stimulated with r-FSH or clomiphene citrate in patients undergoing intrauterine insemination: Analysis of 130 cycles

Aim: The best ovulation induction (OI) protocol in intrauterine insemination (IUI) cycles is still unknown. The aim of this retrospective study was to investigate the effects of two different OI protocols, r-FSH and clomiphene citrate (CC), on the pregnancy rates in IUI cycles. Materials and Methods: One hundred and thirty cycles were retrospectively evaluated in patients who underwent IUI with fresh sperm from their husbands. The study included two treatment arms; the groups consisted of 35 treatment cycles with r-FSH + IUI and 95 treatment cycles with CC + IUI, respectively. The two groups were compared in terms of various clinical and laboratory parameters. Results: The pregnancy rates in r-FSH and CC groups were 17.1% and 10.5%, respectively, and no statistical difference was found (p=0.368). The endometrial thickness (ET) on the day of hCG trigger was less in the CC group (p<0.001). The proportion of patients with ET less than 7 mm was greater in the CC group (p=0.012). However, the pregnancy rates were similar between patients with greater or less than 7 mm of ET in both study groups (p=0.773). Conclusion: Although the ET on the day of hCG trigger was observed to be thinner in the induction protocol with CC compared to the r-FSH group, the pregnancy rates did not differ in the thinner (less than 7 mm) endometrium. Since the pregnancy rates are similar for r-FSH and CC protocols in IUI cycles, CC therapy, which is cheaper and does not include injections, might be an effective option compared to r-FSH therapy for such patients.

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