Intrastromal voriconazole application in the topical treatment of resistant Aspergillus fumigatus keratitis

Topikal tedaviye dirençli Aspergillus fumigatus keratiti tedavisinde intrastromal varikonazol uygulamasının sonuçlarını değerlendirmek amacıyla sunulan bu çalışma girişimsel bir olgu sunumudur. %0.15 (1.5 mg/ml) saatlik topikal amfoterisin B ve günlük sistemik klasik amfoterisin B tedavisine yanıtsızlığı takiben 50 mg/0.1 mL lik vorikonazol solüsyonu infiltrasyonetrafındaki kornea stroma dokus na enjekte edildi ve topikal vorikonazol (%1) damlatıldı. Klinik sonuçlar her vizitte değerlendirildi. Girişim sonrasında korneal infiltrasyonda daha hızlı küçülme ve hastada dramatik tedavi yanıtı gözlendi. İntrastromal vorikonazol enjeksiyonu, geleneksel tedavi yöntemlerine kötü yanıt veren derin yerleşimli inatçı fungal keratit tedavisinde güvenli ve etkili bir yol olabilir.

Aspergillus fumigatus keratitis Topikal tedaviye dirençli Aspergillus fumigatus keratitinde intrastromal vorikonazol uygulaması

To evaluate the results of the application of intrastromal voriconazole in the topical treatment of resistant Aspergillus fumigatus. We present an interventional case report. A 50 mg/0.1 mL solution of voriconazole was injected into the corneal stromal tissue around the infiltration and put on topical voriconazole (1%) after the ulcer had failed to respond to 0.15% (1.5 mg/ml) topical amphotericin B hourly and systemic convantional amphotericin B (0.1 mg/kg) per day. Clinical outcomes were assessed at each visit. After the intervention, a faster reduction in the corneal infiltration and a dramatic therapeutic reponse was observed in the patient.

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