Alev ATILGAN OK, MERİH TEPEOĞLU, Eda AKÇAY YILMAZ, Hakan ÖZKARDEŞ, B. Handan ÖZDEMİR

Human papilloma virus (HPV) negatif verrusiform ksantom: Skrotumda nadir görülen benign tümör

Verrusiform ksantom oldukça nadir görülen ve genellikle oral mukozayı tutan benign bir neoplazidir. Mukoza dışında az sayıda vaka ile vulva, skrotum, penis, anal bölge ve ekstremitelerde yerleştiği bildirilmiştir. Makroskopik görünümü nedeniyle klinik olarak kondiloma aküminatum, verrüköz karsinom ve skuamöz hücreli karsinom ile karışabilir. Ayırıcı tanı için mutlaka lezyonun eksizyonu ve histopatolojik incelemesi gereklidir. Bu lezyonun etyopatogenezi hala tartışmalıdır. Literatürde HPV enfeksiyonu pozitif vakalar bildirilmiştir. Ancak HPV ile ilişkisi net açıklanamamıştır. Bu yazıda, skrotumda yerleşim gösteren bir verrusiform ksantom olgusunu, nadir görülmesi, HPV negatif olması ve klinik olarak malignite ile karışması sebebiyle sunmayı amaçladık.

Verruciform xanthoma with negative human papilloma virus (HPV): Rare benign tumor of scrotum

Verruciform xanthoma is a very rare benign neoplasia that usually involves the oral cavity. It was reported that arises on vulva, scrotum, penis, the anal region and the extremities with a small number of cases outside the mucosa. The macroscopic appearence of the lesion lead to a clinical misdiagnosis of condyloma accuminatum, verrucous carcinoma or squamous cell carcinoma. The excision of the lesion and histopathological examination is required for differential diagnosis. The etiopathogenesis of this lesion is still controversial. HPV positive cases was reported in the literature. But the relationship between HPV and verruciform xanthoma could not be explained. In this report, we aimed to present verruciform xanthoma of the scrotum because of its rarity, HPV negativity and mimics malign lesion, clinically.

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