Çalışmada kemik iliğinde blastik hücre infiltrasyonu gösteren 41 erişkin olguda prolifere hücre nükleer antijeni (PCNA) ve Ki-67 antikorları kullanılarak immünohistokimyasal yöntemle proiiferasyon indeksleri belirlenmiş, her iki antikor ile elde edilen proiiferasyon indeksleri kendi aralarında ve lösemi subtipieri arasında kıyasianmıştır. Tüm olguların ortalama PCNA değerleri %60.2+27.4, Ki-67 indeksleri ise %32.1±19.7'dir. Akut lenfoblastik lösemili (ALL) olgularda ortalama PCNA indeksi %46.1+27.7, akut myeloblastik lösemililerde (AML) %64.0±26.6'dır. Ortalama Ki-67 indeksleri ise ALL ve AM-L'lilerde sırasıyla %31.5+19.1 ve %38.0+18.0'dır. Kronik myelositer lösemiden AML'ye blastik dönüşüm gösteren olgularda ise ortalama PCNA indeksi %64.5+27.5, Ki-67 indeksi %11.2+16.0'dir. AML'Iİ olgularda gerek PCNA, gerekse Ki-67 indeksleri ALL'li olgulardan yüksek bulunmuş, ancak fark istatistiksel olarak anlamlı bulunmamıştır.

An immunohistochemical study using antibodies against proliferating cell nuclear antigen (PCNA) and Ki-67 was performed on 41 adult patients with bone marrow blastic cell infiltrations. The proliferation indices with both markers were compared between each other and different subtypes of blastic cell infiltrations. The mean PCNA index of all cases was 60.2+27.4% and the corresponding value for Ki-67 was 32.1+19.7%. The mean PCNA and Ki-67 indices of cases with acute lym-phoblastic leukemia (ALL) were 46.1+27.7% and 31.5+19.1%, respectively. The same values for acute myeloblastic leukemia (AML) were 64.0+26.6% and 38.0+18.0%, respectively. The cases with chronic myeloid leukemia (CML) showing blastic transformation to AML had a mean PCNA index of 64.5+27.5% and a mean Ki-67 index of 11.2+16.0%. The difference between the PCNA and Ki-67 indices of ALL and AML was not statistically significant.