Çocukluk çağı lupus nefriti izleminde anti-dsDNA düzeyi

Lupus hücrenin nükleer elemalarına karşı antikor üretimi ile karekterli kronik inflamatuvar bir hastalıktır. Doku hasarı patogenezlnde yer alan Anti-dsDNA lupus nefriti (LN) tanı ve izleminde önemli bir yere sahiptir. Çalışmada Akut faz reaktanları ve anti-dsDNA düzeyleri 5 LNTi hastanın (yaş ort.14.0±0.7 yıl) akut ataklarını değerledirmek için kullanıldı. Hastalar başlangıç klinik ve böbrek biyopsi bulgularına göre sınıflandırıld. Hastalığın aktivitivetisi akut faz reaktanları He değerledirildi (yüksek ESH, düşük C3 ve pozitif ANA) ve anti-dsDNA düzeyi He karşılaştırıldı. Hastalar sınıflamalarına göre prednisolon, kolşisin veya siklofosfamid He tedavi edildi, /z/em süresince (7.0±0.7yıl) 4 hastada 5 atak gözlendi. Anti-dsDNA düzeyleri atağın erken fazında ilk artan gösterge oldu. Sonuç olarak anti-dsDNA düzeyi lupus aktivitesii değerlendirmek için erken ve iyi bir göstergedir.

Anahtar Kelimeler:

Akut faz reaksiyonu, Çocuk, Enzim bağlı immünosorbent tayini, Lupus nefriti, Tanı teknik ve işlemleri

Anti-dsDNA levels in the follow up period of lupus nephritis in childhood

Lupus is a chronic inflammatory disease, and characterized by the body's production of antibodies to nuclear components of the cell. It is know that Anti-dsDNA are of primary importance for diagnosis lupus nephritis (LN), appear to play a central role in the pathogenesis of tissue injury. In the study, anti-dsDNA levels and other acute phase reactans are evaluated in activity of five LN patients (mean age 14.0±0.7 years). The patients were classified according to begining of the clinical findings and renal biopsy (WHO classification criteria). Disease activity were evaluated with acute phase reactants; which were high ESR, lower C3 levels, positive ANA and compared with anti-dsDNA levels. The patients were treated with prednisone, chlorochine or cyclophosphamide according to the classification criteria. In the following period (7.0±0.7 years), there were 5 activity attacks in 4 patients. The levels of anti-dsDNA were elevated in early phase of activated LN and correlated with disease activity. In conclusion, anti-dsDNA level is an early and a good index of active lupus nephritis.

Keywords:

Acute-Phase Reaction, Child, Enzyme-Linked Immunosorbent Assay, Lupus Nephritis, Diagnostic Techniques and Procedures,

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