Bu çalışmanın amacı; tedavi almayan Behçet hastalarında lipid metabolizması ile ilgili bazı parametreleri ve antikardiyolipin antikor (AKA) düzeylerini ölçerek sonuçları kontrol grubu ile karşılaştırmak; bu parametrelerin klinik aktivite ile ilişkilerini araştırmaktır Çalışma, 287' erkek, 57 kadın 33 olgu (15'i aktif, 18'i inaktif) ile 17'si erkek, 3'ü kadın 20 sağlıklı gönüllüden oluşan kontrol grubunda yapılmıştır. Behçet hastalığı tanı kriterlerinden en az biri bulunan hastalardan, eritrosit sedimantasyon hızı (ESH) ve C-reaktif protein (CRP) yüksekliği bulunan olgular aktif olgular olarak kabul edilmiştir Behçet' li olgularda HDL düzeyleri kontrol grubuna göre anlamlı olarak düşük bulunmuştur (p

A Study on Some Parameters of Lipid Metabolism and Anticardiolipin Antibody Levels in Behçet's Disease The purpose of this study was to compare some lipid metabolism parameters and the levels of anticardiolipin antibodies (ACA) in sera of patients with Behçet's disease (BD) and 20 healthy controls, and to investigate the relationships between these parameters and the clinical activity of BD in untreated patients 33 patients with BD (28 men and 5 women; 15 have active disease) were admitted to this study and 20 healthy blood donors (17 men and 3 women) served as control group. The patients who have at least one of the diagnostic criteria of BD are classified "active" if they have high levels of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) The patients with BD had significantly lower level of HDL than the controls (p<0.05), and the active cases had significantly lower levels of HDL and apo-A than the controls and the inactive cases (p<0.05). The level of Lp(a) in the active cases was significantly higher than that of control subjects and inactive cases (p<0.05) As far as the levels of ACA-IgG and IgM are concerned, the patients with BD and the active cases had significantly higher levels than control subjects (p <0.05). There was a positive correlation between Lp (a) and CRP (p<0.05) and a negative correlation between the levels of ACA-IgM and the levels of HDL and apo-A in active cases (p<0.05) In conclusion, our study supports the other studies those found low levels of HDL in the patients with BD. High Lp (a) levels might be considered that this lipoprotein behave as an acute phase reactant in the active cases. The increased levels of ACA may allow the development of thrombosis in patients with BD. We recommend that the observed negative correlation between the levels of ACA and the levels of HDL and apo-A should be investigated in the future