Apoptozis ve hücre döngüsü

Normal fizyolojik şartlarda, hasarlı veya yaşlı hücreler, apopitoz (Yn. apo, uzak; ptosis, düşmek) olarak adlandırılan, genetik olarak düzenlenen bir hücre ölüm programıyla kendi kendilerini öldürmektedir. Apototik sürecin temelde nekroz ile morfolojik ve fonksiyonel açılardan ayrımlanması gerekmektedir. Apoptozis, onkogenezis ve hücre döngüsü ile yakın ilişki göstermektedir. Bu nedenle apototik yolakların ortaya konması, bu yolaklarla hücre döngüsü etkileşimlerinde karşılaşılan moleküler mekanizmaların tespiti ve hücre döngüsü ile onun üzerinde inhibitör etki gösteren etkenlerin başta siklinler ve siklin bağımlı kinazlar olmak üzere araştırılması, oldukça büyük önem taşımaktadır. Kök hücre çalışmalarının yoğunluk kazandığı bu son günlerde (neden ilgili kök hücre ör kanser kök hücresimi), bu hücre grubununda, gösterdiği siklus karekteristik özelliklerinin ve bölünme kapasitelerinin incelenmesi, bu derlemeyle ortaya konmaya çalışılmıştır.

Apoptosis and cell cycle

Under normal physiological conditions, damaged or aged cells kill themselves by a genetically regulated cell death program called apoptosis (in Greek apo means -far or distant, and ptosis means -to fall off). The process of apoptosis has to be separated from necrosis by different morphological and functional properties. Apoptosis is closely connected to oncogenesis and the cell cycle. Therefore, it is important to study the apoptotic pathways and to show their corporate interaction with the molecular mechanisms of the cell cycle, especially their influence on cell cycle regulation by cyclins, cyclin-dependent kinases and inhibitors. In particular these days where stem cell research reaches its heights, it is indispensable to show cycle characteristics and division capacities of these cells, which the present review tries to resolve.

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