Yeşiltepe G.R. MUTLU, A. VİTRİNEL, T. AĞZIKURU, S. CÖMERT, G.Ç. ERDAĞ, Y. AKIN

Antiepileptik tedavi alan çocuklarda serum hormon düzeyleri

Amaç: antikonvulsanların serum tiroid hormonları, prolaktin, parathormon ve kalsiyum, fosfor ve alkalen fosfataz düzeyleri üzerine olan etkisini arastırmak Materyal - Metod: En az bir yıl süreyle antikonvulsan tedavi alan yetmis üç epileptik hasta serum tiroid hormonları, prolaktin, parathormon ve kalsiyum, fosfor ve alkalen fosfataz düzeyleri açısından değerlendirildi ve sağlıklı yirmi çocuktan olusan kontrol grubu ile karsılastırıldı. Bulgular: Çalısma grubundaki hastaların kırk dördü (%60.3) erkek, yirmi dokuzu (%39.7) ise kız idi, ortalama yas 6.98±3.34 yıl idi. Hastaların otuz sekizi (%52.1) valproik asit (VPA), yirmibesi (%34.2) karbamazepin (KBZ), sekizi (%11) fenobarbital, ikisi ise (%2.7) vigabatrin almaktaydı. KBZ alan hastalardan birinde (%4) serum serbest T4 düzeyi yüksek iken, VPA alan hastaların ikisinde (%5.26) serbest T4 düzeyi düsük, TSH düzeyi yüksekti. KBZ alan hastaların üçünde (%12) ve VPA alan hastaların ikisinde (%5.3) serum parathormon düzeyi yüksek bulundu. VPA alan bir hastada (%2.63) ve KBZ alan dört hastada (%16) serum prolaktin düzeyi yüksekti.Hastaların hepsinde serum kalsiyum ve fosfor düzeyleri normal sınırlardaydı. Sonuç: Çalısma grubuyla kontrol grubu serum hormon düzeyleri ve kalsiyum, fosfor ve alkalen fosfataz düzeyleri açısından karsılastırıldığında istatistiksel olarak anlamlı fark bulunmadı.

Serum hormone levels of children receiving anticonvulsants

Aim: To determine the effects of anticonvulsants on serum thyroid hormones,prolactin,parathyroid hormone, and calcium,phosphorus,alkaline phosphatase levels. Material - Methods: Seventy three epileptic children receiving anticonvulsants for more than one year were evaluated for serum thyroid hormones,prolactin,parathyroid hormone bone metabolism and compared with control group. Results: Fourty four patients(60.3%)were boys;29 patients(39.7%)girls.Mean age was 6.98±3.34 years.Thirty eight patients(52.1%)were receiving valproic acid,twenty five patients(34.2%)were receiving carbamazepine,eight patients(11%)were receiving phenobarbital and two patients(2.7%)were receiving vigabatrin.Serum free T4 levels were below the normal range in one patient(4%)receiving carbamazepine.Serum free T4 levels were lower and TSH levels were elevated in 2(5.26%)VPA receving patients.Serum parathyroid hormone levels were elevated in three(12%)carbamazepine receiving patients and two(5.3%)VPA receiving patients. Prolactine levels were above the normal range in one patient(2.63%) receiving VPA and four patients (16%)receiving carbamazepine.Serum calcium and phosphorus levels were normal in all control group. Conclusion: There was no significant statistical difference in serum hormone levels and bone metabolism,between study group and control group

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