Püsem PATIR, Gülsüm Akgün ÇAĞLIYAN, Nur SOYER, Nazan ÖZSAN, Filiz VURAL

Akraba dışı allojenik kök hücre nakli ile başarıyla tedavi edilen primer ileal miyeloid sarkom

Miyeloid sarkom, granülositik sarkom veya kloroma olarak da adlandırılan olgunlaşmamış miyeloid hücre proliferasyonunun ekstramedüller tutulumudur. Miyeloid sarkom olgularının sadece %6,5’i gastrointestinal sistemden köken alır. Burada, hastalığın anlaşılmasını arttırmak ve bireyselleştirilmiş tedaviler için bir referans sağlamak amacıyla gastrointestinal sistemden köken alan bir primer myeloid sarkom olgusu sunulmuştur.

Primary ileal myeloid sarcoma successfully treated with unrelated allogeneic stem cell transplantation

Myeloid sarcoma is an extramedullary involvement of immature myeloid proliferation that is also referred to as granulocytic sarcoma or chloroma. Only 6.5% of myeloid sarcomas derive from the gastrointestinal tract. Herein, we present a case of primary myeloid sarcoma originating from the gastrointestinal tract in order to increase understanding of the disease and provide a reference for individualized therapies.

PDF

___

1. Dores GM, Devesa SS, Curtis RE, Linet MS, Morton LM. Acute leukemia incidence and patient survival among children and adults in the United States, 2001-2007. Blood 2012;119(1):34-43.
2. Pileri SA, Ascani S, Cox MC, et al. Myeloid sarcoma: Clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia 2007;21(2):340-50.
3. Narayan P, Murthy V, Su M, Woel R, Grossman IR, Chamberlain RS. Primary myeloid sarcoma masquerading as an obstructing duodenal carcinoma. Case Rep Hematol 2012;2012:490438.
4. Yoldaş T, Erol V, Demir B, Hoşcoşkun C. A rare cause of mechanical obstruction: Intestinal myeloid sarcoma. Ulus Cerrahi Derg 2013;30(3):176-8.
5. Yamauchi K, Yasuda M. Comparison in treatments of nonleukemic granulocytic sarcoma: Report of two cases and a review of 72 cases in the literature. Cancer 2002;94(6):1739-46.
6. Movassaghian M, Brunner AM, Blonquist TM, et al. Presentation and outcomes among patients with isolated myeloid sarcoma: A surveillance, epidemiology and end results database analysis. Leuk Lymphoma 2015;56(6):1698-703.
7. He J, Zhu L, Ye X, et al. Clinical characteristics and prognosis of nonleukemic myeloid sarcoma. Am J Med Sci 2014;347(6):434‑8.
8. Chevallier P, Mohty M, Lioure B, et al. Allogeneic hematopoietic stem‑cell transplantation for myeloid sarcoma: A retrospective study from the SFGM‑TC. J Clin Oncol 2008;26(30):4940-3.
9. Yagi T, Ishikawa J, Takahashi M, et al. Successful treatment of duodenal myeloid sarcoma with allogeneic bone marrow transplantation and additional radiotherapy. Intern Med 2012;51(7):769-72.
10. Chevallier P, Labopin M, Cornelissen J, Socié G, Rocha V, Mohty M; on behalf of the ALWP of EBMT. Allogeneic hematopoietic stem cell transplantation for isolated and leukemic myeloid sarcoma in adults: A report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation. Haematologica 2011;96(9):1391-4.