Orhan ÜREYEN, Olçun Ümit ÜNAL, Demet ALAY, Ayşe YAĞCI, Enver İLHAN

A rare tumor of the pancreas: Anaplastic carcinoma

Anaplastic carcinoma of the pancreas is rarely encountered and usually reported as case reports in the literature. Anaplastic carcinoma is prognosed worse than ductal adenocarcinomas of the pancreas. The effectiveness of chemotherapy and radiotherapy is controversial in the treatment progress. Basic treatment is curative surgery. We aimed to present the management of a case with pancreatic anaplastic carcinoma in which a mass detected at the head of the pancreas and was performed “Whipple” procedure.

Pankreasın nadir bir tümörü: Anaplastik karsinom

Pankreasın anaplastik karsinomu oldukça nadir karşımıza çıkmakta olup literatürde genelde vaka bildirimleri şeklindedir. Anaplastik karsinom pankreasın duktal adenokarsinomlarından daha kötü progrozludur. Tedavisinde kemoterapi ve radyoterapinin etkinliği tartışmalıdır. Temel tedavisi küratif cerrahidir. Biz burada sarılık yakınmasıyla tetkik edilen ve pankreas başında kitle saptanıp ‘‘Whipple’’ prosedürü uyguladığımız pankreas anaplastik karsinomlu bir olgunun yönetimini sunmayı amaçladık.

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1. Clark CJ, Graham RP, Arun JS, Harmsen WS, Reid-Lombardo KM. Clinical outcomes for anaplastic pancreatic cancer: a population-based study. J Am Coll Surg 2012; 215 (5): 627-34.

2. Paal E, Thompson LD, Frommelt RA, Przygodzki RM, Heffess CS. A clinicopathologic and immunohistochemical study of 35 anaplastic carcinomas of the pancreas with a review of the literature. Ann Diagn Pathol 2001; 5 (3): 129-40.

3. Okazaki M, Makino I, Kitagawa H, et al. “A case report of anaplastic carcinoma of the pancreas with remarkable intraductal tumor growth into the main pancreatic duct” World J Gastroenterol 2014; 20 (3): 852–6.

4. Strobel O, Hartwig W, Bergmann F,et al. Anaplastic pancreatic cancer: presentation, surgical management, and outcome. Surgery 2011; 149 (2): 200-8.

5. Hoshimoto S, Matsui J, Miyata R, Takigawa Y, Miyauchi J. “Anaplastic carcinoma of the pancreas: Case report and literature review of reported cases in Japan,” World J Gastroenterol 2016; 22 (38): 8631–7.

6. Oymaci E, Yakan S, Yildirim M, Argon A, Namdaroglu O. “Anaplastic Carcinoma of the Pancreas : A Rare Clinical Entity. Cureus 2017; 9 (10): 1782.

7. Vaithianathan R, Panneerselvam S, Santhanam R. Anaplastic carcinoma of the pancreas: Is there a role for palliative surgical procedure?. Indian J Palliat Care 2014; 20 (1): 50.

8. Yazawa T, Watanabe A, Araki K, et al. Complete resection of a huge pancreatic undifferentiated carcinoma with osteoclast-like giant cells. International Cancer Conference Journal 2017; 6 (4): 193-6.