The Prognostic Role of AB0 Blood Groups In Pancreas Cancer

Previous studies have reported the relationship between the risk of developing pancreatic cancer and blood groups. There have been conflicting results with respect to the prognostic significance of the AB0 blood group in pancreas cancer. We aimed to evaluate the impacts of blood groups on prognosis in our pancreatic cancer patient population. Patients diagnosed with pancreas cancer between January 2014 and December 2018 were analyzed retrospectively. We analyzed the prognostic significance of AB0 blood groups for PDAC (pancreatic ductal adenocarcinoma) patients based on stages of the disease (early stage, locally advanced stage, and metastatic). We evaluated 366 patients diagnosed with pancreatic cancer. The median age of the patients was 65 (27-83). The median overall survival (OS) was 11 months (95%9.49-12.50 months). Median survival based on blood groups were as follows: 13 months for blood group A (95% Cl, 10.59-15.41), 11 months for blood group B (95% Cl, 8.80-13.19), 12 months for blood group AB (95% 6.63-17.36), and eight months for blood group 0 (95% Cl, 5.43-10.56) (p = 0.171). 304 (83.3%) of the patients were not alive at the end of the study. We concluded that the survival of those with 0 blood group was shorter in patients with metastatic pancreatic cancer (p

___

1. Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, et al. Genome-wide association study identifies variants in the AB0 locus associated with susceptibility to pancreatic cancer. Nature genetics 2009; 41: 986-990.

2. Rummel SK, Ellsworth RE. The role of the histoblood AB0 group in cancer. Future Sci. OA 2016; 2: 2.

3. Liumbruno GM, Franchini M. Beyond immunohaematology: the role of the AB0 blood group in human diseases. Blood transfusion 2013; 11: 491.

4. Reilly MP, Li M, He J, et al. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of AB0 with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. The Lancet 2011; 377: 383-392.

5. Borén T, Falk P, Roth KA, et al. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science 1993; 262: 1892-1895.

6. Paré G, Chasman DI, Kellogg M, et al. Novel association of AB0 histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women. PLoS genetics 2008; 4: 7.

7. Hakomori SI. Antigen structure and genetic basis of histo-blood groups A, B and O: their changes associated with human cancer. Biochimica et Biophysica Acta (BBA)-General Subjects 1999; 1473: 247-266.

8. Franchini M, Liumbruno GM, Lippi G. The prognostic value of ABO blood group in cancer patients. Blood Transfusion 2016; 14: 434.

9. Edgren G, Hjalgrim H, Rostgaard K, et al. Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. American journal of epidemiology 2010; 172: 1280-1285.

10. Mao Y, Yang W, Qi Q, et al. Blood groups A and AB are associated with increased gastric cancer risk: evidence from a large genetic study and systematic review. BMC cancer 2019; 19: 164.

11. Nakao M, Matsuo K, Hosono S, et al. AB0 blood group alleles and the risk of pancreatic cancer in a Japanese population. Cancer Sci 2011; 102: 1076-1080.

12. El Jellas K, Hoem D, Hagen K, et al. (2017) Associations between AB0 blood groups and pancreatic ductal adenocarcinoma: influence on resection status and survival. Cancer Med 2017; 6: 1531-1540.

13. Wang D, Wang Z, Zhang L, et al. Are risk factors associated with outcomes in pancreatic cancer? PLoS One 2012; 7: 7.

14. Williams H, Jajja MR, Hashmi SS, et al. Association of AB0 blood group with survival following pancreatoduodenectomy for pancreatic ductal adenocarcinoma. HPB 2020; 4.

15. Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal. Cancer statistics. Ca Cancer J Clın 2016; 667-630.

16. Kanji ZS, Gallinger S. Diagnosis and management of pancreatic cancer. Cmaj 2013; 185: 1219-1226.

17. Klein AP. Identifying people at a high risk of developing pancreatic cancer. Nat Rev Cancer 2013; 13: 66-74.

18. Wolpin BM, Chan AT, Hartge P, et al. ABO blood group and the risk of pancreatic cancer. Journal of the National Cancer Institute 2009; 101: 424-431.

19. Dandona M, Gao F, Linehan DC, Wang-Gillam A. AB0 blood group and the risk of pancreatic cancer. J Natl Cancer Inst 2010; 102: 135-137.

20. Huang JY, Wang R, Gao YT, Yuan JM. AB0 blood type and the risk of cancer–Findings from the Shanghai Cohort Study. PloS one 2017; 12(9).

21. Rahbari NN, Bork U, Hinz U, et al. AB0 blood group and prognosis in patients with pancreatic cancer. BMC Cancer 2012; 12: 319-322.

22. Ben Q, Wang K, Yuan Y, Li Z. Pancreatic cancer incidence and outcome in relation to AB0 blood groups among Han Chinese patients: a case-control study. Int J Cancer 2011; 128: 1179-186.

23. Engin H, Bilir C, Ustun H, Gokmen A. AB0 blood group and risk of pancreatic cancer in a Turkish population in Western Blacksea region. Asian Pac J Cancer Prev 2012; 13: 131-133.

24. Rawla P, Sunkara T, Gaduputi V. Epidemiology of pancreatic cancer: global trends, etiology and risk factors. World journal of oncology 2019; 10: 10.
Eastern Journal of Medicine-Cover
  • ISSN: 1301-0883
  • Başlangıç: 1996
  • Yayıncı: ERBİL KARAMAN
Sayıdaki Diğer Makaleler

The Prognostic Role of AB0 Blood Groups In Pancreas Cancer

Sema TÜRKER, Ebru ÇILBIR, Deniz Can GÜVEN, Hayriye ŞAHİNLİ, Cengiz KARAÇİN, NAZIM KUNDURACI

Premenarchal Ovarian Torsion: Ten Years of Experience of A Tertiary Center

Deniz DİRİK, Burhan BEGER, Tuba YANGILAR OKYAY, Lokman SOYSAL, Erbil KARAMAN

Drug-Drug Interactions In The Risky Population: Elderly, Urological Patients Admitted To The Intensive Care Unit

Muhammet Serdar BUĞDAY, Ersoy ÖKSÜZ

An Experimental Study That Investigates Effects of Atreleuton in Metabolic Syndrome

TEVFİK NOYAN, Sertaç Burhanettin AYHAN

Shaping Efficiency of WaveOne Gold and One Curve in Simulated J-Shaped Root Canals

Ayfer ATAV ATEŞ, Burçin ARICAN

Impact of YouTube platform in the Realm of Interventional Cardiology Techniques Such as: Double Kissing Crush

Flora OZKALAYCI, Emrah ERDOĞAN

The Levels of CRP in Non-Complicated Patients With Total Laparoscopic Hysterectomy and its Role in Predicting Vaginal Cuff Hematoma

Pınar KADİROĞULLARI, Hüseyin KIYAK, Erkan ŞİMŞEK, Emine KARABÜK, Kerem SEÇKİN

The Relationship Between Smoking and Gastric Histopathology in Patients Presented to the Emergency Department with Dyspeptic Complaints and Underwent Endoscopic Examination

Mehmet Ali BİLGİLİ

Idiopathic Granulomatous Mastitis and Other Types of Mastitis; Comparison of Ultrasound Findings

Nurşen TOPRAK, Ali Mahir GÜNDÜZ

Radiological Findings of Acute Calcific Tendinitis of the Longus Colli Muscle

Firuze OCAK, Murat BEYHAN, Erkan GÖKÇE