The alteration of life quality between hormone treatment-receiving and non-receiving early-stage prostate cancer patients who underwent radiotherapy

The purpose of this prospective study was to compare the life qualities of radiotherapy-receiving early-stage prostate cancer patients during their controls done prior to, at the last week of, and 3 months after, the radiotherapy procedure. Curative surgery or radiotherapy is the treatment of choice in localized prostate cancer. Androgen deprivation therapy, which is performed according to the risk groups, is effective in the downsizing of the prostate. The European Organization for Research and Treatment of Cancer Quality of Life Questionna ire EORT-QLQ C30 is an effective means of evaluating the quality of life on the basis of the individual’s physical and functional scales. 35 prostate cancer patients who had not undergone surgery and who received curative radiotherapy were included in the study. The study was performed prospectively. The life qualities and weights of prostate cancer patients were evaluated before, at the end of, and 3 months after, the radiotherapy sessions, by means of the EORTC-QLQ 30 Test. The alterations encountered in hormone-receiving patients on the basis of physical, emotional, perceptional, and social scores, in addition to fatigue, nausea, vomiting and pain evaluations, done on the basis of the EORTC-QLQ 30 measurements performed prior to, at the end of and 3 months after, the radiotherapy sessions, were found to be statistically significant (p

___

Newcomer LM, Stanford JL, Blumenstein BA, Brawer MK. Temporal trends in rates of prostate cancer: declining incidence of advanced stage disease, 1974 to 1994. J Urol 1997;158:1427–30.

Mottet N, Bellmunt J, Briers E, et al. Guidelines on Prostate Cancer, 2016. https://uroweb.org/wp-content/uploads/EAUGuidelines- Prostate-Cancer-2016-1.pdf.

Connolly RM, Carducci MA, Antonarakis ES. Use of androgen deprivation therapy in prostate cancer: indications and prevalence. Asian Androl 2012;14:177-86.

Pilepich MV, Krall JM, al-Sarraf M, John MJ, Doggett RL, Sause WT, et al. Androgen deprivation with radiation therapy compared with radiation therapy alone for locally advanced prostatic carcinoma: a randomized comparative trial of the Radiation Therapy Oncology Group. Urolology 1995;45: 616-23.

D’Amico AV, Schultz D, Loffredo M, Dugal R, Hurwitz M, Kaplan L, et al. Biochemical outcome following external beam radiation therapy with or without androgen suppression therapy for clinically localized prostate cancer. JAMA 2000;284: 1280-3

Potosky AL, Haque R, Cassidy-Bushrow AE, et al. Effectiveness of primary androgen-deprivation therapy for clinically localized prostate cancer. J Clin Oncol 2014; 32:1324-30.

Casey RG, Corcoran NM, Goldenberg SL. Quality of life issues in men undergoing androgen deprivation therapy: a review. Asian J Androl 2012; 14:226-31.

Jan J. Heimans Martin J. B. Taphoorn Impact of brain tumour treatment on quality of life. J Neurol (2002) 249: 955–960 DOI 10.1007/s00415-002-0839-5

Osoba D, Rodrigues G, Myles J, Zee B, Pater J. Interpreting the significance of changes in healthrelated quality-of-life scores. J Clin Oncol 1998; 16: 139-44.

Hiram G, Jeff M, Daniel A. H, John T. W, Rodney L D, Eric K, Howard M S, Chris S, Mark L, Deborah K, Larry H, Peter C, Martin G. S, and the PROSTQA Consortium. Neoadjuvant androgen deprivation therapy (NADT) Leads to Immediate Impairment of Vitality/ Hormonal and Sexual Quality of Life: Results of a MultiCenter, Prospective Study. Urology. 2013 December; 82(6): 1363–1368. doi:10.1016/j.urology.2013.06.062.

Janda M, Gerstner N, Obermair A, Fuerst A, Wachter S, Dieckmann K, Pötter R. Quality of life changes during conformal radiation therapy for prostate carcinoma. Cancer 2000; 89: 1322-8.

Michael B, Matthew R. S, Wendy R. P, Padraig W, Richard C, Andrea B, Peter K, Matthew P, Clare M, Jean P B, Mahesh K.B. P, Karen S, Bingshu E. C, and Malcolm D. M. Impact of Radiotherapy When Added to Androgen Deprivation Therapy for Locally Advanced Prostate Cancer: LongTerm Quality-of-Life Outcomes From the NCIC CTG PR3/MRC PR07 Randomized Trial. JOURNAL OF CLINICAL ONCOLOGY. 33:2151-2157. JULY 1 2015 by American Society of Clinical Oncology.

Nazmiye Kocaman Y, Nesiba K, Mine Ö. Yetişkin Kanser Hastalarının Destekleyici Bakım Gereksinimleri ve Verilen Hizmet Arasındaki Boşluk. Dokuz Eylül Üniversitesi Hemşirelik Yüksekokulu Elektronik Dergisi. DEUHYO ED 2013,6 (4), 231-240.

G. Rodrigues, A. Bezjak, D. Osoba, P. Catton, D. Tsuji, D. Taylor& P. Warde. The relationship of changes in EORTC QLQ-C30 scores to ratings on the Subjective Significance Questionnaire in men with localized prostate cancer. Quality of Life Research 13: 1235–1246, 2004. 2004 Kluwer Academic Publishers. Printed in the Netherlands.

Fayers P, Aaronson N, Bjordal K, et al. EORTC QLQ-C30 Scoring Manual. Brussels, Belgium, Quality of Life Unit, EORTC Data Centre, 1995.

Osoba D, Zee B, Bezjak A, et al. Interpreting the significance of health-related quality of life scores: The relationship of changes in scores on the EORTC QLQ-C30 with ratings on the Subjective Significance Questionnaire. Qual Life Res, in press.

Irene M. Lips, Carla H. van Gils, Uulke A. van der Heide, Arto E. Boeken Kruger and Marco van Vulpen. Health-related quality of life 3 years after high-dose intensity-modulated radiotherapy with gold fiducial marker-based position verification. 2 0 0 8 T H E A U T H O R S 7 6 2 J O U R N A L C O M P I L A T I O N 2 0 0 8 B J U I N T E R N A T I O N A L | 1 0 3, 7 6 2 – 7 6 7 | doi:10.1111/j.1464-410X.2008.08117.

Pardo Y, Guedea F, Aguilo´ F, et al. Quality-oflife impact of primary treatments for localized prostate cancer in patients without hormonal treatment. J Clin Oncol 2010; 28: 4687–96.

Barry MJ. Quality of life and prostate cancer treatment. J Urol 1999;162:407.

Nora E, Sandra N, Maike S, Alexander K, Volker R, Annika W.. The ProCaSP study: quality of life outcomes of prostate cancer patients after radiotherapy or radical prostatectomy in a cohort study. Eisemann et al. BMC Urology (2015) 15:28 DOI 10.1186/s12894-015-0025-6.

Pearce A, Choo R, Danjoux C, Morton G, Loblaw DA, Szumacher E, Cheung P, Deboer G, Chander S. Int J Radiat Oncol Biol Phys 2006; 65: 78-83.

Geinitz H, Thamm R, Scholz C, et al. Longitudinal analysis of quality of life in patients receiving conformal radiation therapy for prostate cancer. Strahlenther Oncol 2010; 186: 46-52.

John W. R, Bryan J. D, Jodi E. S, John C. S, Scott D. E, John C. R, Kiril T, Harold L, Cheryl S, and Bejoy T. A Randomized Trial of External Beam Radiotherapy Versus Cryoablation in Patients With Localized Prostate Cancer. Cancer October 15, 2009.

Michael P, MD, PhD, Vanessa B, MD, Marsha S, MD, Barbara K, MD, and Michael J. Eble, MD, PhD. Quality of Life After Radiation Therapy for Prostate Cancer With a Hydrogel Spacer: 5-Year Results. Radiation Oncology International Journal of biology physics. Received Mar 6, 2017, and in revised form May 16, 2017. Accepted for publication May 22, 2017.
Eastern Journal of Medicine-Cover
  • ISSN: 1301-0883
  • Başlangıç: 1996
  • Yayıncı: ERBİL KARAMAN