In this study, our aim is to evaluate the quality of life, depression and anxiety of the Syrian patients who have brain metastasis and their relatives before starting radiotherapy and to correlate their depression and anxiety after radiotherapy. Brain metastases are frequently considered the last stage in many cancers. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30, Beck Depression Inventory, and State-Trait Anxiety Inventory I-II test questionnaires were administered upon the arrival of 51 Syrian immigrant patients with brain metastases and their relatives to a radiotherapy clinic. Beck Depression Inventory, and State-Trait Anxiety Inventory questionnaires II were administered after radiotherapy. Beck Depression Inventory performed before and after radiotherapy in patients and their relatives and Beck Depression Inventory analysis was significant (p
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1.Ellis TL, Neal MT, Chan MD. The role of surgery, radiosurgery and whole brain radiation therapy in the management of patients with metastatic brain tumors. Int J Surg Oncol 2012; 2012: 952345.
2. Who Preamble to the Constitution of the World Health Organization as adopted by the International Health Conference. Proceedings of the Official Records of the World Health Organization 1948 Apr 7; 1946 Jun 19-22; New York, NY, U.S.A.; 1946. Available from: http://www.who.int/about/definition/en/pri nt.html, accessed on September 10, 2008
3. Heimans JJ, Taphoorn MJ. Impact of brain tumour treatment on quality of life. J Neurol 2002; 249: 955-960.
4. Tannock IF. Treating the patient, not just the cancer. N Engl J Med 1987; 317: 1534-1535.
5. Richter P, Werner J, Heerlein A, Kraus A, Sauer H. On the validity of the Beck Depression Inventory. A review. Psychopathology 1998; 31: 160-168.
6. Giovagnoli AR, da Silva AM, Federico A, Cornelio F. On the personal facets of quality of life in chronic neurological disorders. Behav Neurol 2009; 21: 155-163.
7. Validation of the Arabic version of the EORTC quality of life questionnaire among cancer patients in Lebanon. August 2013; 22: 1473-1481.
8. Ahmed M Abdel-Khalek. The development and validation of an Arabic form of the STAI: Egyptian results. Personality and Individual Differences 1989; 10: 277-285.
9. Ahmed m abdel-khalek. Internal cosistency of an arabic adaptation of the beck depression inventory in four arab countries. Psychological Reports 1998; 82: 246-266.
10. Khuntia D, Brown P, Li J, Mehta MP. Wholebrain radiotherapy in the management of brain metastasis. J Clin Oncol 2006; 24: 1295-1304.
11. Marlon Garzo Saria, Natasia S. Courchesne, Lorraine Evangelista, Joshua L. Carter, Daniel A. MacManus,Mary Kay Gorman, Adeline M. Nyamathi, Linda R. Phillips, David E. Piccioni,Santosh Kesari. Sally L. Malisk. Anxiety and Depression Associated With Burden in Caregivers of Patients With Brain Metastases 2017; 44: 306-315.
12. McKernan M, McMillan DC, Anderson JR, Angerson WJ, Stuart RC. The relationship between quality of life (EORTC QLQ-C30) and survival in patients with gastrooesophageal cancer. Br J Cancer 2008; 98: 888-893.
13. Jan J.Heimans Martin J. B.Taphoorn. Impact of brain tumour treatment on quality of life.J Neurol 2002; 249: 955-960.
14. Gotay CC, Blaine D, Haynes SN, Holup J, Pagano IS. Assessment of quality of life in a multicultural cancer patient population. Psychol Assess 2002; 14: 439-450.
15. Mete HE, Önen Ö. Kanserli hastalarda depresyon. Duygudurum Dizisi 2001; 4: 184- 191.
16. Baral I, Enderer M, Turgay M. Kanserli hastaların yakınlarında hastalıgın çesitli evrelerinde saptanan psikiyatrik durum. NöroPsikiyatri Arsivi 1995; 32: 141-146.
17. Kim SH, Son BH, Hwang SY, et al. Fatigue and depression in disease-free breast cancer survivors: prevalence, correlates, and association with quality of life. J Pain Symptom Manage 2008; 35: 644-655.
18. Mehnert A, Koch U. Psychological comorbidity and health-related quality of life and its association with awareness, utilization, and need for psychosocial support in a cancer register-based sample of long-term breast cancer survivors. J Psychosom Res 2008; 64: 383-391.
19. Giovagnoli AR, Tamburini M, Boiardi A. Quality of life in brain tumor patients. J Neurooncol 1996; 30: 71-80.
20. Moyer A, Salovey P. Predictors of social support and psychological distress in women with breast cancer. J Health Psychol 1999; 4: 177-191.
21. Anna R Giovagnoli. Quality of life in patients with stable disease after surgery, radiotherapy, and chemotherapy for malignant brain tumour. J Neurol Neurosurg Psychiatry 1999; 67: 358-363.
22. Ell K, Sanchez K, Vourlekis B, et al. Depression, correlates of depression, and receipt of depression care among low-income women with breast or gynecologic cancer. J Clin Oncol 2005; 23: 3052-3060.
23. Dalton SO, Schuz J, Engholm G, et al. Social inequality in incidence of and survival from cancer in a population-based study in Denmark, 1994-2003: summary of findings. Eur J Cancer 2008; 44: 2074-2085.
24. Skarstein J, Aass N, Fossa SD, Skovlund E, Dahl AA. Anxiety and depression in cancer patients: relation between the hospital anxiety and depression scale and the European organization for research and treatment of cancer core quality of life questionnaire. J Psychosom Res 2000; 49: 27-34.
25. Spiegel D, Giese-Davis J. Depression and cancer: mechanisms and disease progression. Biol Psychiatry 2003; 54: 269-282.
26. Pitceathly C, Maguire P. The psychological impact of cancer on patients' partners and other key relatives: a review. Eur J Cancer 2003; 39: 1517-1524.
27. Wittmann V, Latos M, Horvath Z, et al. What contributes to long-term quality of life in breast cancer patients who are undergoing surgery? Results of a multidimensional study. Qual Life Res 2017; 26: 2189-2199.
28. Salander P, Bergenheim T, Henriksson R. The creation of protection and hope in patients with malignant brain tumours. Soc Sci Med 1996; 42: 985-996.
29. Giovagnoli A. Quality of life in patients with stable disease after surgery. J Neurol Neurosurg Psychiatry 1999; 67: 358-363.
30. Bottino SM, Fráguas R, Gattaz WF. Depressão e câncer. Rev Psiq Clin 2009; 36: 10915.