Silver Nanoparticles; A New Hope In Cancer Therapy?

Nowadays, with the rapid developments in nanotechnology, there has been a significant increase in the usage of nanoparticles within the biomedical field. Nanoparticles are known as particles ranging in size between 1 and 100 nm. Especially, silver nanoparticles (AgNPs) have been extensively carried out biomedical are as because of their physicochemical, and biological therapeutic properties. Recent studies have shown that there are anti-fungal, anti-viral, anti-inflammatory, anti-angiogenic biological activities, especially anti-bacterial and anti-cancer features of silver nanoparticles. Also, the appropriate knowledge of these characteristics is crucial since this knowledge enhances their potential usage in many areas while decreasing their possible dangers for human and environment. Recent researches demonstrate that multifunctional cytotoxic biological activities of biosynthesized silver nanoparticles can be used as an anti-cancer agent. In this work, it is aimed to give a literature review of the studies on silver nanoparticles, synthesis techniques and their possible usages especially in cancer therapy.

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1. Albrecht MA, Evan CW, Raston CR. Green chemistry and the health implications of nanoparticles. Green Chem 2006; 8: 417-432.

2. Osuwa JC, Anusionwu PC. Some advances and prospects in nanotechnology: a review. Asian J Inf Technol 2011; 10: 96-100.

3. Sriram MI, Kalishwaralal K, Barathmanikanth S, Gurunathani S. Size-based cytotoxicity of silver nanoparticles in bovine retinal endothelial cells. Nanosci Methods 2012; 1: 56-77.

4. He Y, Li X, Wang J, et al Synthesis, characterization and evaluation cytotoxic activity of silver nanoparticles synthesized by Chinese herbal Cornus officinalis via environment friendly approach. Environ Toxicol Pharmacol 2017; 56: 56-60.

5. Zhu B, Li Y, Lin Z, et al. Silver Nanoparticles Induce hepg-2 Cells Apoptosis Through ROSMediated Signaling pathways. Nanoscale Res Lett 2016; 11: 198.

6. Malik MA, O’Brien P, Revaprasadu N. A simple route to the synthesis of core/shell nanoparticles of chalcogenides. Chemistry of Materials 2002; 14: 2004-2010.

7. Thakkar KN, Mhatre SS, Parikh RY. Biological synthesis of metallic nanoparticles. Nanomedicinee 2010; 6: 257-262.

8. Parikh RY, Singh S, Prasad BLV, Patole MS, Sastry M, Schouche YS. Extracellular synthesis of crystalline silver nanoparticles and molecular evidence of silver resistance from Morganella sp.: towards understanding biochemical synthesis mechanism. ChemBioChem 2008; 9: 1415-1422.

9. Pugazhenthiran N, Anandan S, Kathiravan G, Prakash NKU, Crawford S, Ashokkumar M. Microbial synthesis of silver nanoparticles by Bacillus sp. Journal of Nanoparticle Research 2009; 11: 1811-1815.

10. Gurunathan S, Kalishwaralal K, Vaidyanathan R, et al. Biosynthesis, purification and characterization of silver nanoparticles using Escherichia coli. Colloids and Surf B Biointerfaces 2009; 74: 328-335.

11. Loo CY, Rohanizadeh R, Young PM, et al. Combination of Silver Nanoparticles and Curcumin Nanoparticles for Enhanced Antibiofilm Activities. J Agric Food Chem 2016; 64: 2513-2522.

12. Moyer CA, Brentano L, Gravens D, Margraf HW, Monafo WW. Treatment of large human burns with 0.5% silver nitrate solution. Arch Surg 1965; 90: 812-867.

13. Silver S. Bacterial silver resistance: molecular biology and uses and misuses of silver compounds. FEMS Microbiol Rev 2003; 27: 341-353.

14. Silver S, Phung LT, Silver G. Silver as biocides in burn and wound dressings and bacterial resistance to silver compounds. J Ind Microbiol Biotechnol 2006; 33: 627-634.

15. Klasen HJ. Historical review of the use of silver in the treatment of burns. I. Early uses. Burns 2000a; 26: 117-130.

16. Klasen HJ. A historical review of the use of silver in the treatment of burns. II. Renewed interest for silver. Burns 2000b; 26: 131-138.

17. Wei L, Lu J, Xu H, Patel A, Chen ZS, Chen G. Silver nanoparticles: synthesis, properties, and therapeutic applications. Drug Discov Today. 2015; 20: 595-601.

18. Raghunandan D, Ravishankar B, Sharanbasava G, et al. Anti-cancer studies of noble metal nanoparticles synthesized using different plant extracts. Cancer Nanotechnol 2011; 2: 57-65.

19. Asharani PV, Hande MP, Valiyaveettil S. Antiproliferative activity of silver nanoparticles. BMC Cell Biology 2009; 10: 65.

20. Greulich C, Diendorf J, Simon T, Eggeler G, Epple M. Uptake and intracellular distribution of silver nanoparticles in human mesenchymal stem cells. Acta Biomaterialia 2011; 7: 347- 354.

21. Kim S, Choi JE, Choi J, et al. Oxidative stressdependent toxicity of silver nanoparticles in human hepatoma cells. Toxicology in Vitro 2009; 23: 1076-1084.

22. Héctor RH, Salma JB, Pedro PMC, et al. Effects of 45-nm silver nanoparticles on coronary endothelial cells and isolated rat aortic rings. Toxicology Lett 2009; 191: 305- 313.

23. Hsin YH, Chen CF, Huang S, Shih TS, Lai PS, Chueh PJ. The apoptotic effect of nanosilver is mediated by a ROS- and JNK dependent mechanism involving the mitochondrial pathway in NIH3T3 cells. Toxicology Lett 2008; 179: 130-139.

24. Sanpui P, Chattopadhyay A, Ghosh SS. Induction of apoptosis in cancer cells at low silver nanoparticle concentrations using chitosan nanocarrier. ACS Appl Mater Interfaces 2011; 3: 218-228.

25. Ahamed M, Karns M, Goodson M, et al. DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells. Toxicology and Applied Pharmacology 2008; 233: 404-410.

26. Sukirtha R, Manasa Priyanka K, Antony JJ, Kamalakkannan S, Balasubramanian P. Cytotoxic effect of Green synthesized silver nanoparticles using Melia azedarach against in vitro HeLa cell lines and lymphoma mice model. Process Biochemistry 2012; 47: 273- 279.

27. Kalishwaralal K, Banumathi E, Ram KPS, et al. Silver nanoparticles inhibit VEGF induced cell proliferation and migration in bovine retinal endothelial cells. Colloids and Surfaces B: Biointerfaces 2009; 73: 51-57.

28. Sriram MI, Kanth SBM, Kalishwaralal K, Gurunathan S, Antitumor activity of silver nanoparticles in Dalton’s lymphoma ascites tumor model. Inter J Nanomedicine 2010; 5: 753-762.

29. Mukherjee S, Chowdhury D, Kotcherlakota R, et al. Potential theranostics application of biosynthesized silver nanoparticles (4-in-1 system). Theranostics. 2014; 4: 316-335.

30. Ovais M, Khalil AT, Raza A, et al. Multifunctional theranostic applications of biocompatible green-synthesized colloidal nanoparticles. Appl Microbiol Biotechnol. 2018 Mar 29

31. Ovais M, Raza A, Naz S, et al. Current state and prospects of the phytosynthesized colloidal gold nanoparticles and their applications in cancer theranostics. Appl Microbiol Biotechnol 2017; 101: 3551-3565.

32. Mandal RP, Mandal G, Sarkar S, Bhattacharyya A, De S. "Theranostic" role of bile salt-capped silver nanoparticles - gall stone/pigment stone disruption and anticancer activity. J Photochem Photobiol B. 2017; 175: 269-281.

33. Gurunathan S, Raman J, Malek SNA, John PA, Vikineswary S. Green synthesis of silver nanoparticles using Ganoderma neojaponicum Imazeki: a potential cytotoxic agent against breast cancer cells. Int J Nanomedicine 2013; 8: 4399-4413.

34. Nazir S, Hussain T, Iqbal Md, Mazhar K, Muazzam AG, Ismail J Md. Novel and costeffective green synthesis of silver nanoparticles and their in vivo antitumor properties against humancancer cell lines. Biosci Tech 2011; 2: 425-443.

35. Guo D, Zhu L, Huang Z, et al. Anti-leukemia activity of PVP-coated silver nanoparticles via generation of reactive oxygen species and release of silver ions. Biomaterials 2013; 34: 7884-7894.

36. Saratale RG, Benelli G, Kumar G, Kim DS, Saratale GD. Biofabrication of silver nanoparticles using the leaf extract of an ancient herbal medicine, dandelion (Taraxacum officinale), evaluation of their antioxidant, anticancer potential, and antimicrobial activity against phytopathogens. Environ Sci Pollut Res 2018; 25: 10392– 10406.

37. Kuppusamy P, Ichwan SJ, Al-Zikri PN, et al. In Vitro Anticancer Activity of Au, Ag Nanoparticles Synthesized Using Commelina nudiflora L. Aqueous Extract Against HCT116 Colon Cancer Cells. Biol Trace Elem Res 2016; 173: 297-305

38. El-Naggar NE, Hussein MH, El-Sawah AA. Bio-fabrication of silver nanoparticles by phycocyanin, characterization, in vitro anticancer activity against breast cancer cell line and in vivo cytotoxicity. Sci Rep 2017; 7: 10844.

39. Kathiravan V, Ravi S, Ashokkumar S. Synthesis of silver nanoparticles from Melia dubia leaf extract and their in vitro anticancer activity. Spectrochim Acta A Mol Biomol Spectrosc 2014; 130: 116-121.

40. Nagajyothi PC, Sreekanth TVM, Lee JI, Lee KD. Mycosynthesis: antibacterial, antioxidant and antiproliferative activities of silver nanoparticles synthesized from Inonotus obliquus (Chaga mushroom) extract. J Photochem Photobiol B Biol 2014; 130: 299- 304.

41. Rathi Sre PR, Reka M, Poovazhagi R, Arul Kumar M, Murugesan K. Antibacterial and cytotoxic effect of biologically synthesized silver nanoparticles using aqueous root extract of Erythrina indica lam. Spectrochim Acta Part A Mol Biomol Spectrosc 2015; 135: 1137- 1144.

42. Krishnaraj C, Muthukumaran P, Ramachandran R, Balakumaran MD, Kalaichelvan PT. Acalypha indica Linn: biogenic synthesis of silver and gold nanoparticles and their cytotoxic effects against MDA-MB-231, human breast cancer cells. Biotechnol Rep 2014; 4: 42-49.

43. Sathishkumar G, Gobinath C, Wilson A, Sivaramakrishnan S. Dendrophthoe falcata (L.f) Ettingsh (Neem mistletoe): a potent bioresource to fabricate silver nanoparticles for anticancer effect against human breast cancer cells (MCF7). Spectrochim Acta Part A Mol Biomol Spectrosc 2014; 128: 285-290.

44. Gajendran B, Chinnasamy A, Durai P, Raman J, Ramar M. Biosynthesis and characterization of silver nanoparticles from Datura inoxia and its apoptotic effect on human breast cancer cell line MCF7. Mater Lett 2014; 122: 98-102.

45. Jacob SJP, Finub JS, NarayananA. Synthesis of silver nanoparticles using Piper longum leaf extracts and its cytotoxic activity against Hep2 cell line. Colloids Surf B Biointerfaces 2012; 91: 212-214.

46. Govindaraju K, Krishnamoorthy K, Alsagaby SA, Singaravelu G, Premanathan M. Green synthesis of silver nanoparticles for selective toxicity towards cancer cells. IET Nanobiotechnol 2015; 9: 325-330.

47. Kaler A, Jain S, Banerjee UC. Green and rapid synthesis of anticancerous silver nanoparticles by Saccharomyces boulardii and insight into mechanism of nanoparticle synthesis. Biomed Res Int 2013; 2013: 872-940.

48. Alsalhi MS, Devanesan S, Alfuraydi AA, et al.. Green synthesis of silver nanoparticles using Pimpinella anisum seeds: antimicrobial activity and cytotoxicity on human neonatal skin stromal cells and colon cancer cells. Int J Nanomedicine 2016; 11: 4439-4449.

49. Vijayan R, Joseph S, Mathew B. Indigofera tinctoria leaf extract mediated green synthesis of silver and gold nanoparticles and assessment of their anticancer, antimicrobial, antioxidant and catalytic properties. Artif Cells Nanomed Biotechnol 2018; 46: 861-871.

50. Oh KH, Soshnikova V, Markus J, et al.. Biosynthesized gold and silver nanoparticles by aqueous fruit extract of Chaenomeles sinensis and screening of their biomedical activities. Artif Cells Nanomed Biotechnol 2018; 46: 599-606.

51. Yakop F, Abd Ghafar SA, Yong YK, et al. Silver nanoparticles Clinacanthus Nutans leaves extract induced apoptosis towards oral squamous cell carcinoma cell lines. Artif Cells Nanomed Biotechnol 2018; 1-9.