Relationship Between Red Cell Distribution Width and Serum C Reactive Protein Levels In Maintenance Hemodialysis Patients

We aimed to investigate the relationship between RDW and serum CRP levels in maintenance hemodialysis patients. We enrolled 112 eligible maintenance hemodialysis patients in this retrospective study. Two groups were i dentified according to red cell distribution width (RDW) values: patients with normal RDW (RDW < 14.5%) and patients with elevated RDW (RDW ≥ 14.5%). Spearman correlation analysis and linear regression analysis were used to investigate the relationship between the study parameters. The only statistically significant difference between two groups was serum CRP levels (p= 0.007). Se rum albumin levels had significant but weak inverse correlation with serum CRP levels (r= -0.257, p= 0.006). RDW values had significant but weak positive correlation with serum CRP levels (r= 0.289, p= 0.002). We did not found a significant correlation between hemoglobin levels and serum CRP levels and serum ferritin levels and serum CRP levels (p= 0.090 and p= 0.664, respectively). We made multivariate linear regression analysis and RDW was detected as the only independently associated factor for serum CRP levels (p= 0.028). We found that there is a statistically significant positive correlation between CRP and RDW in maintenance hemodialysis patients. We also showed a significant relationship between RDW and serum CRP levels. We concluded that RDW can be used as an inflammatory marker for hemodialysis patients.

___

1. Coresh J. Update on the Burden of CKD. J Am Soc Nephrol 2017; 28: 1020-1022.

2. Collins AJ, Foley RN, Gilbertson DT, Chen S-C (2015) United States Renal Data System public health surveillance of chronic kidney disease and end-stage renal disease. Kidney Int Suppl 2011; 5: 2-7.

3. Zimmermann J, Herrlinger S, Pruy A, Metzger T, Wanner C. Inflammation enhances cardiovascular risk and mortality in hemodialysis patients. Kidney international 1999; 55: 648-658.

4. de Francisco ALM, Stenvinkel P, Vaulont S (2009) Inflammation and its impact on anaemia in chronic kidney disease: from haemoglobin variability to hyporesponsiveness. NDT Plus 2 (Suppl_1):i18-i26. doi:10.1093/ndtplus/sfn176

5. Eleftheriadis T, Kartsios C, Antoniadi G, Kazila P, Dimitriadou M, Sotiriadou E, Koltsida M, Golfinopoulos S, Liakopoulos V, ChristopoulouApostolaki M. The Impact of Chronic Inflammation on Bone Turnover in Hemodialysis Patients. Renal Failure 2008; 30: 431-437.

6. Heidari B. C-reactive protein and other markers of inflammation in hemodialysis patients. Caspian J Intern Med 2013; 4: 611-616.

7. Evans TC, Jehle D. The red blood cell distribution width. The Journal of emergency medicine 1991; 1: 71-74.

8. Roberts GT, El Badawi SB. Red blood cell distribution width index in some hematologic diseases. American journal of clinical pathology 1985; 83: 222-226.

9. Zalawadiya SK, Veeranna V, Panaich SS, Afonso L, Ghali JK. Gender and ethnic differences in red cell distribution width and its association with mortality among low risk healthy United state adults. The American journal of cardiology 2012; 109: 1664-1670.

10. Felker GM, Allen LA, Pocock SJ, ET AL. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. Journal of the American College of Cardiology 2007; 50: 40-47.

11. Shao Q, Korantzopoulos P, Letsas KP, Tse G, Hong J, Li G, Liu T. Red blood cell distribution width as a predictor of atrial fibrillation 2018; 32 (5): e22378.

12. Lu Y-A, Fan P-C, Lee C-C, et al. Red cell distribution width associated with adverse cardiovascular outcomes in patients with chronic kidney disease. BMC Nephrol 2017; 18: 361-361.

13. Zorlu A, Bektasoglu G, Guven FM, et al. Usefulness of admission red cell distribution width as a predictor of early mortality in patients with acute pulmonary embolism. The American journal of cardiology 2012; 109: 128-134.

14. Macdougall IC, Cooper AC. Erythropoietin resistance: the role of inflammation and pro inflammatory cytokines. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant AssociationEuropean Renal Association 2002; 11: 39-43.

15. Niki E, Komuro E, Takahashi M, Urano S, Ito E, Terao K. Oxidative hemolysis of erythrocytes and its inhibition by free radical scavengers. The Journal of biological chemistry 1988; 263: 19809- 19814.

16. Solak Y, Yilmaz MI, Saglam M, et al. Red cell distribution width is independently related to endothelial dysfunction in patients with chronic kidney disease. The American journal of the medical sciences 2014; 347: 118-124.

17. Vashistha T, Streja E, Molnar MZ, et al. Red Cell Distribution Width and Mortality in Hemodialysis Patients. American journal of kidney diseases : the official journal of the National Kidney Foundation 2016; 68: 110-121.

18. Tekce H, Kin Tekce B, Aktas G, Tanrisev M, Sit M. The Evaluation of Red Cell Distribution Width in Chronic Hemodialysis Patients. International Journal of Nephrology 2014; 2014: 6.

19. Hosmer Jr DW, Lemeshow S, & Sturdivant R. Model building strategies and methods for logistic regression. In: Applied logistic regression 2013; 398. John Wiley & Sons.

20. Cobo G, Lindholm B, Stenvinkel P. Chronic inflammation in end-stage renal disease and dialysis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2018; 33: 35-40.

21. Kaur M. C-reactive Protein: A Prognostic Indicator. Int J Appl Basic Med Res 2017; 7: 83- 84.

22. Docci D, Bilancioni R, Buscaroli A, et al. Elevated serum levels of C-reactive protein in hemodialysis patients. Nephron 1990; 56: 364-367.

23. Carrero JJ, Stenvinkel P. Inflammation in endstage renal disease--what have we learned in 10 years? Seminars in dialysis 2010; 23: 498-509.

24. Skjelbakken T, Lappegard J, Ellingsen TS, et al. Red cell distribution width is associated with incident myocardial infarction in a general population: the Tromso Study. Journal of the American Heart Association 2014; 3.

25. Feng G-H, Li H-P, Li Q-L, Fu Y, Huang R-B. Red blood cell distribution width and ischaemic stroke. Stroke and Vascular Neurology 2017; 2: 172-175.

26. Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G. Red blood cell distribution width: A simple parameter with multiple clinical applications. Critical reviews in clinical laboratory sciences 2015; 52: 86-105.

27. Yonemoto S, Hamano T, Fujii N, et al. Red cell distribution width and renal outcome in patients with non-dialysis-dependent chronic kidney disease. PloS one 2018; 13: e0198825.

28. Chen X, Shen B, Zou J, et al. The Prognostic Value of Red Blood Cell Distribution Width in Patients on Maintenance Hemodialysis. Blood purification 2016; 42: 314-321.
Eastern Journal of Medicine-Cover
  • ISSN: 1301-0883
  • Başlangıç: 1996
  • Yayıncı: ERBİL KARAMAN
Sayıdaki Diğer Makaleler

Isolated Pneumopericardium After Penetrating Chest Injury

Hasan EKİM, Meral EKIM

Retrospective Evaluation of Patients with Hairy Cell Leukemia: A Decade Experience at a Single Center

Mehmet BAYSAL, Volkan BAŞ, Sedanur KARAMAN GÜLSARAN, Ali Caner ÖZDÖVER, Elif ÜMİT, Hakkı Onur KIRKIZLAR, Fulya ÖZPUYAN, Ahmet Muzaffer DEMİR

Correlation Between Change In Respiratory Muscle Strength And Cough Ability In Patients Submitted To Open-Heart Surgery

Karan PONGPANİT, Chitima KULCHANARAT, Sasipa BURANAPUNTALUG, Kornanong YUENYONGCHAİWAT

Association Between Endothelial Nitric Oxide Synthase Polymorphisms T786C and G894T and Ischaemic Stroke

Vedat ÇİLİNGİR, Ahmet DÖNDER, AYSEL MİLANLIOĞLU, Abdullah YILGÖR, Temel TOMBUL

Evaluation of Accuracy and Reliability of Electrocardiographs Interpreted By Emergency Medicine Assistants

Mehmet Reşit ÖNCÜ, FATMA ÖZDEMİR, Şule AKKÖSE AYDIN

Coronary Artery Anomalies and Variations Detected In Computed Tomography Angiography

Ali Mahir GÜNDÜZ

Coexistence of Autism and Ring Chromosome 22

Esra SİZER, Tuğba YÜKSEL, Diclehan ORAL

Evaluation of Intraocular Pressure and Central Corneal Thickness Changes After Hemodialysis In Patients With Chronic Renal Failure

SEYFETTİN ERDEM, Müslüm GÜNEŞ

Management of Incidental Amyand Hernia With A Case Report

Tolga KALAYCI, ÜMİT HALUK İLİKLERDEN

Nurses as a New Stakeholder in Genetics and The Place of Genetics in Educational Processes: A Study From Turkey

Ayşe YACAN KÖK, ÇİĞDEM AYDIN ACAR