Evaluatıon of Neutrophıl-To-Lymphocyte Ratıo and Mean Platelet Volume In Patıents With Hyperthyroıdısm

Both Lymphocytes and platelets play an important role in the pathogenesis of Graves' disease (GD), a chronic inflammatory autoimmune disease. The mean platelet volume (MPV), which is considered as an indirect indicator of platelet function, may be increased as an inflammatory marker in GD. The aim of this study is to prove that the autoimmune, chronic inflammatory pathogenesis of GD can be demonstrated by evaluating the whole blood count parameters A total of 75 patients of which 41 were diagnosed as GD and 34 were diagnosed as TNG were included in the study. Complete blood count parameters were evaluated in both groups before treatment and after treatment when euthyroidism was achieved. In GD group, pretreatment MPV values were significantly higher than TNG group (p: 0.021). There was a statistically significant decrease in NLR in GD group compared to TNG group after treatment (p: 0,025). Although there was no statistically significant difference, lymphocyte count was higher in GD group compared to TNG group be fore treatment. The monocyte count was significantly higher in the GD group compared to the TNG group before treatment (p: 0.006). There was no correlation between MPV and free T3, free T4, TSH values before and after treatment in GD group. These results suggest that autoimmunity and inflammation in GD are reflected in whole blood count parameters and that MPV elevation in GD is related to autoimmunity rather than the metabolic effect of thyroid hormones.

___

1. De Leo S, Lee SY, Braverman LE. Hyperthyroidism. Lancet 2016; 388: 906-918.

2. Brent, Gregory A. Graves' Disease. The new england journal of medicine. 2008.

3. Duprez L, Hermans J, Van Sande J, Dumont JE, Vassart G, Parma J. Two Autonomous Nodules of a Patient with Multinodular Goiter Harbor Different Activating Mutations of the Thyrotropin Receptor Gene. The Journal of Clinical Endocrinology & Metabolism 1997; 82: 306-308.

4. Holzapfel HP, Fuhrer D, Wonerow P, Weinland G, Scherbaum WA, Paschke R. Identification of constitutively activating somatic thyrotropin receptor mutations in a subset of toxic multinodular goiters. J Clin Endocrinol Metab 1997; 82: 4229-4233.

5. Tomczynska M, Saluk-Bijak J. The mutual cooperation of blood platelets and lymphocytes in the development of autoimmune thyroid diseases. Acta Biochim Pol 2018; 65: 17-24.

6. Kuznik BI, Vitkovsky YA, Gvozdeva OV, Solpov AV, Magen E. Lymphocyte-platelet crosstalk in Graves' disease. Am J Med Sci 2014; 347: 206-210.

7. Turan E. Evaluation of neutrophil-tolymphocyte ratio and hematologic parameters in patients with Graves' disease. Bratisl Lek Listy 2019; 120: 476-480.

8. Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med 2012; 5: 2.

9. Turkmen K, Guney I, Yerlikaya FH, Tonbul HZ. The relationship between neutrophil-tolymphocyte ratio and inflammation in endstage renal disease patients. Ren Fail 2012; 34: 155-159.

10. Tomczynska M, Salata I, Bijak M, Saluk-Bijak J. The potential contribution and role of a blood platelets in autoimmune thyroid diseases. J Cell Mol Med 2018; 22: 6386-6390.

11. Bagir GS, Haydardedeoglu FE, Bakiner OS, Bozkirli E, Ertorer ME. Mean Platelet Volume in Graves' disease: A Sign of Hypermetabolism Rather than Autoimmunity? Pak J Med Sci 2017; 33: 871-875.

12. Panzer S, Haubenstock A, Minar E. Platelets in hyperthyroidism: studies on platelet counts, mean platelet volume, 111-indium-labeled platelet kinetics, and platelet-associated immunoglobulins G and M. J Clin Endocrinol Metab 1990; 70: 491-496.

13. Atılgan Ü. C. Şendül S.Y, Kösekahya P., Çağlayan M., Alkan A., Güven D., Yılmazbaş P., Evaluation of Neutrophil-to-Lymphocyte Ratio and Mean Platelet Volume in Patients with Active and Inactive Thyroid Orbitopathy. The Medical Bulletin Of Sisli Etfal Hospital 2018; 52: 26-30.

14. Celik T. Neutrophil-to-lymphocyte ratio in thyroid ophthalmopathy. Bratisl Lek Listy 2017; 118: 495-498.
Eastern Journal of Medicine-Cover
  • ISSN: 1301-0883
  • Başlangıç: 1996
  • Yayıncı: ERBİL KARAMAN
Sayıdaki Diğer Makaleler

Accommodation Spasm Following Tetanus Diphtheria (Td) Vaccination

MUHAMMED BATUR, Tuncay ARTUÇ, ERBİL SEVEN, Serek TEKİN

Evaluating Edentulous Mandible Alveolar Crest Dimensions in Posterior Region By Cone Beam Computed Tomography

Alaettin KOÇ, Ruşen ERDEM

Comparing The Effects of Sugammadex and Neostigmine On Neuromuscular Block and Bispectral Index In Recovery From Intracranial Mass Resection Operations

Mustafa KURÇALOĞLU, Bahriye Binnur SARIHASAN, Erhan Çetin ÇETİNOĞLU

The Effect of N-acetylcysteine on Amylase, Electrolytes, Vitamins and Nitrosative Stress Levels in Rats Treated with Maras Powder

Velid UNSAL, Ergul BELGE KURUTAS

Salmonella Ovarian Abscess In A Patient With Systemic Lupus Erythematosus Presented As Acute Abdomen: A Case Report And Review Of The Literature

Ali İrfan BARAN, Mahmut SUNNETCİOGLU, Umit YAKAN, Abdussamet BATUR, Ergenekon KARAGOZ, Mustafa Kasim KARAHOCAGİL

Relationship Between Serum Asymmetrical Dimethylarginine Level and Urolithiasis

Özgür YAZICI, Kadriye AYDİN, Sule TEMİZKAN, Fehmi NARTER, Akif ERBİN, Alper KAFKASLI, Alkan ÇUBUK, Rahmi ASLAN, Kemal SARICA

Retrospective Evaluation of Our Patients With Lymphadenopathy

Serap KARAMAN, Enver USLU, Murat BAŞARANOĞLU, Tülay KAMAŞAK, Eda ÇELEBİ BİTKİN

Ovarian Torsion During Pregnancy: A Case of Malignant Ovarian Cancer

Latif HACIOĞLU, Erbil KARAMAN, Deniz DİRİK, Onur KARAASLAN, Ali KOLUSARI, Hanım Güler ŞAHİN, Abdulaziz GÜL

Isolated Single Umbilical Artery: Implications For Pregnancy

Mehmet Nafi SAKAR, Süleyman Cemil OĞLAK, Süreyya DEMİR, Hüseyin GÜLTEKİN, Bülent DEMİR

The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey

Gonca GÜLBAY, Elif YESİLADA, Mehmet Ali ERKURT, Harika GÖZÜKARA BAĞ