Compatibility of Na and K values measured by biochemistry analyser and blood gas analyser in different clinical situations

Severe disturbances in sodium and potassium are frequently encountered in emergency departments and these are among the most important treatable medical emergencies. In this study we aimed to evaluate the correlation of serum sodium and potassium levels measured with blood gas analyser (BGA) and biochemistry laboratory autoanalyser (BLA) devices in the laboratory. We conducted a retrospective study between April 1st and 30th, in an emergency department of an university hospital. We screened patients whom had both venous blood gas analysis and serum electrolytes in biochemistry panel. Then we grouped electrolyte levels of patients as hyper-, hypo-, and eu- to compare these groups separately. Pearson correlation coefficients were calculated for determination linear relationships between the variables. Results: total of 156 patients (age> 18) screened whom had both venous blood gas analysis and serum electrolytes in biochemistry panel at the same emergency appointment. The mean level of sodium in serum samples was 138.7 mmol/l compared to 143.2 mmol/l in venous blood gas. Mean variation between two samples was -4.46 mmol/l (95% CI -5.25, -3.67), ranged from -19 mmol/l to 4 mmol/l. The mean level of potassium in serum samples was 4.34 mmol/l compared to 3.74 mmol/l in venous blood gas. Mean variation between two samples was 0.6 mmol/l (95% CI 0.50, 0.69) ranged from -0.50 mmol/l to 2.6 mmol/l. The correlation coefficient was found r=0.852 for Na, r=0.774 for K and p was <0.001 for both values. We found positive correlation in sodium and potassium levels in various strength in different clinical situations. As our opinion, blood gas analyses should help and guide physicians especially in emergent conditions.

___

1. Mehdi Mirzazadeh, Alireza Morovat, Tim James et al. Point-of-care testing of electrolytes and calcium using blood gas analysers: it is time we trusted the results. Emerg Med J 2015; 0: 1-6.

2. Quinn LM, Hamnett N, Wilkin R, Sheikh A. Arterial blood gas analysers: accuracy in determining haemoglobin, glucose and electrolyte concentrations in critically ill adult patients. Br J Biomed Sci 2013; 70: 97-100.

3. Zhang JB, Lin J, Zhao XD. Analysis of bias in measurements of potassium, sodium and hemoglobin by an emergency department-based blood gas analyzer relative to hospital laboratory autoanalyzer results. PLoS One 2015; 10: e0122383.

4. Jain A, Subhan I, Joshi M. Comparison of the point-of-care blood gas analyzer versus the laboratory auto-analyzer for the measurement of electrolytes. Int J Emerg Med 2009; 2: 117-120.

5. Centers for Medicare & Medicaid Services. Clinical Laboratory Improvement Amendments (CLIA). Baltimore: CMS, 2013 (www.cms.gov/Regulations-andGuidance/Legislation/CLIA/ index.html?redirect=/clia/).

6. Chacko B, Peter JV, Patole S, Fleming JJ, Selvakumar R. Electrolytes assessed by point- ofcare testing-are the values comparable with results obtained from the central laboratory? Indian J Crit Care Med 2011; 15: 24-29.

7. Budak YU, Huysal K, Polat M. Use of a blood gas analyzer and a laboratory autoanalyzer in routine practice to measure electrolytes in intensive care unit patients. BMC Anesthesiol 2012; 12: 17.

8. Morimatsu H, Rocktaschel J, Bellomo R, Uchino S, Goldsmith D, Gutteridge G. Com- parison of point-of-care versus central laboratory measurement of electrolyte concentrations on calculations of the anion gap and the strong ion difference. Anesthesiology 2003; 98: 1077-1084.

9. Bloom BM, Connor H, Benton S, Harris T. A comparison of measurements of sodium, potassium, haemoglobin and creatinine between an Emergency Department-based point- of-care machine and the hospital laboratory. Eur J Emerg Med 2014; 21: 310-313.

10. Solak Y. Comparison of serum sodium levels measured by blood gas analyzer and biochemistry autoanalyzer in patients with hyponatremia, eunatremia, and hypernatremia. Am J Emerg Med 2016; 34: 1473-1479.

11. Kozacı N, Ay MO, Güven R, Şaşmaz İ, Karaca A Comparison of Na, K, Cl, Hb and Hct values measured by blood gas analyzer and laboratory auto-analyzer 2015; 40: 343-347.
Eastern Journal of Medicine-Cover
  • ISSN: 1301-0883
  • Başlangıç: 1996
  • Yayıncı: ERBİL KARAMAN