Selvihan BEYSEL, Erman ÇAKAL, Mustafa ÖZBEK, Mahmut APAYDIN, Mustafa ÇALIŞKAN

Subklinik Hipotiroidili Hastalarda Tiroksin Tedavisinin Kardiyovasküler Risk Faktörleri Üzerine Etkisi

Amaç: Subklinik hipotiroidizm (SH) kardiyovasküler risk faktörleri (KVR) üzerinde zararlı bir etkiye sahiptir; ancak tedavi edilip edilmemesi halen tartışmalıdır. Çalışmanın amacı, SH hastaların KVR’ini belirlemek ve kısa süreli tiroksin tedavisinin bunlara etkisini araştırmaktır. Gereç ve Yöntemler: Bu retrospektif çalışmaya SH grubu(n=30) ve yaş-cinsiyet eşleştirilmiş kontrol grubu (n=40) dahil edildi. SH hastalarına 3 ay boyunca 50 μg/gün tiroksin tedavisi verildi. Tedaviden önceki KVR, tedaviden sonraki KVR ile karşılaştırıldı. Bulgular: Kontrol (kadın %66,7; yaş 45,76±14,55 yıl) ve SH (kadın %77,3; yaş 45,23±12,02 yıl) grubu arasında, cinsiyet dağılımı ve yaş ortalaması benzerdi (p>0,05). Vücut kitle indeksi (VKİ) SH grubunda (32,66±5,57 kg/m2), kontrol grubundan (25,13±3,20 kg/m2) daha yüksekti. Başlangıçta, SH grubunda serum glukoz (83,76±9,51 vs 91,73± 9,96 mg/dl), toplam kolesterol (162,36±13,41 vs 184,21±51,91 mg/dl), düşük-yoğunluklu lipoprotein-kolesterol (LDLC; 91,73±22,04 vs 104,61±11,36 mg/dl), C-reaktif protein (hs-CRP; 1,53±0,66 vs 2,63±0,93 mg/L) düzeyi, kontrol grubuna göre daha yüksekti (p

The Effect of Thyroxine Therapy on Cardiovascular Risk Factors in Patients with Subclinical Hypothyroidism

Aim: Subclinical hypothyroidism (SH) has a deleterious effect on cardiovascular risk factors (CVR); however it shouldbe treated or not is stil controversial. The aim of our study is to determine CVR in patients with SH, and to investigatethe short term effect of thyroxine treatment on CVR.Material and Methods: Patients with SH (n=30), and age- and sex-matched control group (n=40) were included in thisretrospective study. SH patients were treated by 50μg/day thyroxine for 3 months. Pre-treatment CVR was comparedwith post-treatment CVR.Results: Sex distribution and mean age were similar between control (female 66.7%; age 45.76±14.55 years) and SH(female 77.3%; age 45.23±12.02 years) groups (p>0.05). Body mass index (BMI) was high in SH group (32.66±5.57kg/m2) than in control group (25.13±3.20 kg/m2, p

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