Canan EREN, İlker Nihat ÖKTEN, Ayten GÜNER AKBIYIK

Kan Grupları ile Akciğer Kanseri Riski Arasındaki İlişkilerin Histolojiye Bağlı Analizi

Amaç: Kan grubu antijenleri, keşfedilen ilk genetik belirteçlerdir. Kırmızı kan hücre zarlarından eksprese edilen ABO kan gruplarının çeşitli çalışmalarda malignite riski ile ilişkili olduğu gösterilmiştir. Bu çalışmanın amacı, kan grupları ile akciğer kanseri arasında bir ilişki olup olmadığını araştırmaktır. Gereç Yöntemler: Çalışmamızda ABO ve Rh kan grubu serolojik olarak doğrulanmış 587 akciğer kanserli hasta gözden geçirildi. Hastalar kan gruplarına (O, A, B, AB), Rh faktörü (+, -) ve histolojik akciğer kanseri tiplerine göre [Küçük Hücreli Dışı Akciğer kanseri (KHDAK) ve Küçük Hücreli Akciğer Kanseri (KHAK)] sınıflandırıldı. KHDAK’nin adenokarsinom (AK) ve skuamöz karsinom (SK) alt tipleri kaydedildi. ABO / Rh kan gruplarının yaş, cinsiyet ve histolojik alt tip gibi klinik özelliklerle ilişkisi değerlendirildi. Bulgular: Patolojik analiz sonucu ile O, A, B ve AB kan grupları arasında anlamlı bir ilişki bulunmadı. Çalışmada KHAK'li olgularda B Rh (-) kan grubuna sahip olan hastaların oranı, KHDAK'li olanlardan daha yüksek bulundu. Sonuç: Akciğer kanseri riski ile ABO kan grupları arasında bir ilişki olduğu görüldü. Rh faktörü tek başına etkili olmamakla beraber B Rh (-) kan grubuna sahip olan hastalar KHAK açısından daha fazla riske sahip olabilir. Kan grubu alt tiplerinin akciğer kanseri hücreleriyle moleküler düzeyde ilişkisinin incelenmesi, akciğer kanseri ve kan grupları arasındaki ilişkiyi açıklığa kavuşturmak için yararlı olacaktır.

Analysis of The Relationship between Blood Groups and Lung Cancer Risk Depending on Histology

Aim: Blood group antigens are the first genetic markers discovered. ABO blood groups which are expressed on redblood cell membranes are reported to be associated with malignancy risk. The present study aimed to investigatewhether there is an association between blood groups and patients with lung cancer.Material and Methods: In our study, ıt was reviewed 587 patients with lung cancer whose ABO/Rh blood types wereserologically confirmed. Patients were classified according to blood groups (O, A, B, AB), Rh factor (+, −) andhistological types of lung cancer as Non-small cell lung carcinoma (NSCLC) and Small cell lung carcinoma (SCLC).The adenocarcinoma (AC) and squamous carcinoma (SC) as subtypes of NSCLC were recorded. The relationship ofABO/Rh blood groups with clinical features, such as age, sex and histological subtype were evaluated.Results: There was no significant association between pathological results and blood groups O, A, B and AB. SCLCpatients had significantly higher frequency of blood type B Rh (-) when compared to NSCLC patients.Conclusion: We observed an association between risk of lung cancer and ABO blood groups. Although the Rh factor isnot effective by itself, patients with the B Rh (-) blood group may have a higher risk than SCLC. Examining therelationship of blood group subtypes with lung cancer cells at the molecular level would be useful to clarify therelationship between lung cancer and blood groups.

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