Tip 2 Diyabetli Bireylerde Aterojenik Plazma İndeksi ile İlişkili Visseral Adipozite İndekslerinin Değerlendirilmesi

Amaç: Bu çalışmanın amacı tip 2 diyabet (T2DM) hastalarında visseral yağlanma göstergelerini ve aterojenik plazma indeksini (atherogenic index of plasma, AIP) araştırmaktır. Gereç ve Yöntemler: Bu çalışmaya 18 ve 74 yaşları arası toplam 353 yetişkin birey dahil edildi. Vücut ağırlığı, boy uzunluğu, bel ve kalça çevresi ölçüldü; açlık kan şekeri, HbA1c ve lipid profil (total kolesterol, trigliserit, düşük dansiteli lipoprotein kolesterol ve yüksek dansiteli lipoprotein kolesterol) değerleri analiz edildi. Visseral adipozite indeksi (visceral adiposity index, VAI), lipit birikim ürünü (lipid accumulation product, LAP), vücut adipozite indeksi (body adiposity index, BAI), vücut şekli indeksi (body shape index, ABSI), vücut yuvarlaklık indeksi (body roundness index, BRI), koniklik indeksi (conicity index, CI) ve AIP seviyeleri hesaplandı. Bulgular: Çalışmaya, yaş ortalaması 57,8±11,5 yıl olan 116 (%32,9) erkek ve 237 (%67,1) kadın dahil edildi. AIP z-skorlarının doğrudan T2DM ile ilişkili olduğu (OR, 5,03; %95 GA: 1,95-13,01), VAI z-skorlarının T2DM ile daha az ilişkili olduğu (OR, 1,10; %95 GA: 1,03-1,18) belirlendi. ROC eğrisi analizine göre, eğri altında kalan alan (area under the curve, AUC) VAI, LAP ve AIP ile diyabetik hastaları ayırt etmekte zayıf olsa da istatistiksel olarak anlamlıdır (sırasıyla p<0,001; AUC: 0,619; kesme değeri= 5,1; %95 GA: 0,561-0,677; p=0,007; AUC: 0,583; kesme değeri= 63,2; %95 GA: 0,523-0,642 ve p=0,001; AUC: 0,606; kesme değeri= 0,4; % 95 GA: 0,547-0,665). Sonuç: VAI, LAP ve AIP diyabetin güçlü prediktörleridir, AIP diyabeti öngörmede VAI ve LAP’den daha iyi bir prediktördür.

Anahtar Kelimeler:

Aterojenik plazma indeksi, visseral adipozite indeksi, lipid birikim ürünü, tip 2 diyabet

Evaluation of Visceral Adiposity Indexes Associated with Atherogenic Plasma Index in Individuals with Type 2 Diabetes

Aim: This study was aimed to investigate visceral adiposity indicators and the atherogenic index of plasma (AIP) in type 2 diabetes mellitus (T2DM) patients. Material and Methods: A total of 353 adults aged between 18 and 74 years were included in this study. Bodyweight, height, waist, and hip circumference were measured; fasting blood glucose, HbA1c, and lipid profile (total cholesterol, triglyceride, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol) values were analyzed. Visceral adiposity index (VAI), lipid accumulation product (LAP), body adiposity index (BAI), body shape index (ABSI), body roundness index (BRI), conicity index (CI), and AIP levels were calculated. Results: The study included 116 (32.9%) males and 237 (67.1%) females, with a mean age of 57.8±11.5 years. AIP z-scores were found to be directly related to T2DM (OR, 5.03; 95% CI: 1.95-13.01), while VAI z-scores were less associated with T2DM (OR, 1.10; 95% CI: 1.03-1.18). According to the ROC curve analysis, although the area under the curve (AUC) is weak to distinguish diabetic patients with VAI, LAP, and AIP, it is statistically significant (p<0.001, AUC: 0.619, cut-off= 5.1, 95% CI: 0.561-0.677; p=0.007, AUC: 0.583, cut-off= 63.2, 95% CI: 0.523-0.642; and p=0.001, AUC: 0.606, cut-off= 0.4, 95% CI: 0.547-0.665, respectively). Conclusion: VAI, LAP, and AIP are strong predictors of diabetes, AIP is a better predictor of predicting diabetes than VAI and LAP.

Keywords:

Atherogenic plasma index, visceral adiposity index, lipid accumulation product, type 2 diabetes,

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