Obsessive compulsive symptoms presented during the course of chronic normal pressure hydrocephalus: a case report

Normal pressure hydrocephalus (NPH) is usually presented with psychiatric symptoms. Obsessive compulsive disorder (OCD) and NPH comorbidity is rare and there are only few case reports on this topic. Our case who had chronic NPH secondary to intracranial hemorrhage presented with obsessive compulsive (OC) symptoms while he was treated at neurology inpatient clinic for epilepsy. He benefited from sertraline and quetiapine treatment. Our case is thought to be the first case in terms of comorbidity of chronic NPH and OC symptoms in Turkey.

Kronik normal basınçlı hidrosefali sürecinde gelişen obsesif kompulsif belirtiler: Bir olgu sunumu

Normal basınçlı hidrosefali (NBH) sıklıkla psikiyatrik bulgular sergiler. Obsesif kompulsif bozukluk (OKB) ve NBH komorbiditesi nadirdir ve bu konuda birkaç olgu bildirimi bulunmaktadır. Olgumuz intrakraniyal kanamaya sekonder kronik NBH gelişen ve epilepsi tanısı ile nöroloji servisinde yatışı sırasında obsesif kompulsif (OK) belirtiler sergileyen bir olgudur. Sertralin ve ketiapin tedavisinden fayda görmüştür. Kronik NBH, OK belirtiler komorbiditesi açısından ülkemizde ilk vaka olduğu düşünülmektedir.

PDF

___

Adams RD, Fisher CM, Hakim S, Ojemann RG, Sweet WH. Symptomatic occult hydrocephalus with normal cerebrospinalfluid pressure: a treatable syndrome. N Engl J Med 1965; 273:117-126. [CrossRef]

de Oliveira MF, Pinto FCG, Nishikuni K, Botelho RV, Lima AM, Rotta JM. Revisiting hydrocephalus as a model to study brain resilience. Front Hum Neurosci 2016; 10:375.

Gomes Pinto FC, de Oliveira MF. Response to journal club: role of endoscopic third ventriculostomy and ventriculoperitoneal shunt in idiopathic normal pressure hydrocephalus: preliminary results of a randomized clinical trial. Neurosurgery 2013; 73:911- 912. [CrossRef]

Kito Y, Kazui H, Kubo Y, Yoshida T, Takaya M, Wada T, Nomura K, Hashimoto M, Ohkawa S, Miyake H, Ishikawa M, Takeda M. Neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus. Behav Neurol 2009; 21:165-174. [CrossRef]

Oliveira MF, Oliveira JR, Rotta JM, Pinto FC. Psychiatric symptoms are present in most of the patients with idiopathic normal pressure hydrocephalus. Arq Neuropsiquiatr 2014; 72:435-438. [CrossRef]

McIntyre AW, Emsley RA. Shoplifting associated with normalpressure hydrocephalus: report of a case. J Geriatr Psychiatry Neurol 1990; 3:229-230. [CrossRef]

Kwentus JA, Hart RP. Normal pressure hydrocephalus presenting as mania. J Nerv Ment Dis 1987; 175:500-502. [CrossRef]

Bloom KK, Kraft WA. Paranoia an unusual symptom of hydrocephalus. Am J Phys Med Rehabil 1998; 77:157-159. [CrossRef]

Yusim A, Anbarasan D, Bernstein C, Boksay I, Dulchin M, Lindenmayer JP, Saavedra-Velez C, Shapiro M, Sadock B. Normal pressure hydrocephalus presenting as Othello syndrome: case presentation and review of the literature. Am J Psychiatry 2008; 165:1119-1125. [CrossRef]

Abbruzzese M, Scarone S, Colombo C. Obsessive-compulsive symptomatology in normal pressure hydrocephalus: a case report. J Psychiatry Neurosci 1994; 19:378-380.

Kaufman Y, Newman JP, Boneh O, Ben-Hur T. Normal pressure hydrocephalus manifesting as an obsessive-compulsive disorder responding to CSF drainage. J Neurol 2003; 250:622-623. [CrossRef]

Mendhekar DN, Sharma A, Inamdar A. Obsessive-compulsive disorder with hydrocephalus: effect of ventricular shunting. J Neuropsychiatry Clin Neurosci 2007; 19:84. [CrossRef]

Scarone S, Colombo C, Livian S, Abbruzzese M, Ronchi P, Locatelli M, Scotti G, Smeraldi E. Increased right caudate nucleus size in obsessive-compulsive disorder: detection with magnetic resonance imaging. Psychiatry Res 1992; 45:115-121. [CrossRef]

Robinson D, Wu H, Munne RA, Ashtari M, Alvir JM, Lerner G, Koreen A, Cole K, Bogerts B. Reduced caudate nucleus volume in obsessive-compulsive disorder. Arch Gen Psychiatry 1995; 52:393-398. [CrossRef]

Rubin RT, Villaneuva-Meyer J, Anath J, Trajmar PG, Mena I. Regional xenon 133 cerebral blood flow and cerebral technetium 99m HMPAO uptake in unmedicated patients with obsessivecompulsive disorder and matched normal control subjects. Determination by high-resolution single-photon emission computed tomography. Arch Gen Psychiatry 1992; 49: 695-702. [CrossRef]

Adams BL, Warneke LB, McEwan AJ, Fraser BA. Single photon emission computerized tomography in obsessive compulsive disorder: a preliminary study. J Psychiatry Neurosci 1993; 18:109-112.

Edmonstone Y, Austin MP, Prentice N, Dougall N, Freeman, CP, Ebmeier KP, Goodwin GM. Uptake of 99m Tc-exametazime shown by single photon emission computerized tomography in obsessive-compulsive disorder compared with major depression and normal controls. Acta Psychiatr Scand 1994; 90:298-303. [CrossRef]

Swedo SE, Schapiro MB, Grady CL, Cheslow DL, Leonard HL, Kumar A, Friedland R, Rapoport SI, Rapoport JL. Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Arch Gen Psychiatry 1989; 46:518-523. [CrossRef]

Nordahl TE, Benkelfat C, Semple WE, Gross M, King AC, Cohen RM. Cerebral glucose metabolic rates in obsessive compulsive disorder. Neuropsychopharmacology 1989; 2:23-28. [CrossRef]

Behar D, Rapoport JL, Berg CJ, Denckla MB, Mann L, Cox C, Fedio P, Zahn T, Wolfman MG. Computerized tomography and neuropsychological test measures in adolescents with obsessive-compulsive disorder. Am J Psychiatry 1984; 141:363- 369. [CrossRef]

Stein DJ, Hollander E, Chan S, DeCaria CM, Hilal S, Liebowitz MR, Klein DF. Computed tomography and neurological soft signs in obsessive-compulsive disorder. Psychiatry Res 1993; 50:143-150. [CrossRef]

Owler BK, Pickard JD. Normal pressure hydrocephalus and cerebral blood flow: a review. Acta Neurol Scand 2001; 104:325- 342. [CrossRef]

Owens MJ, Risch SC. Atypical antipsychotics. In AF Schatzberg, CB Nemeroff (eds), Textbook of Psychopharmacology (2nd ed). Washington, DC: American Psychiatric Press, 1998; 323-348.

Mishra BR, Sarkar S, Mishra S, Praharaj SK, Mahapatra P, Sinha VK. Antipsychotic sensitivity in normal pressure hydrocephalus. Gen Hosp Psychiatry 2011; 33:83.e11-3. [CrossRef]

Macias CG, Diaz RA, Montano MG, Marguez SF, Dominguez MR, Blanco BR, Gonzalez LH. EPA-0544 - Dementia in patients with Obsessive Compulsive Disorder (OCD). Eur Psychiatry 2014; 29(Suppl.1):1. [CrossRef]

Cankurtaran ES. Behavioral and psychological symptoms in Alzheimer’s disease. Update in Psychiatry 2013; 3:216-223. (Turkish)

Rascovsky K, Neuhaus J, Kramer JH, Miller BL, Seeley WW. Obsessive-compulsive symptoms in Alzheimer’s disease and frontotemporal dementia. Alzheimers Dement 2009; 5:504. [CrossRef]

Frydman I, Ferreira-Garcia R, Borges MC, Velakoulis D, Walterfang M, Fontenelle LF. Dementia developing in late-onset and treatment-refractory obsessive-compulsive disorder. Cogn Behav Neurol 2010; 23:205-208. [CrossRef]

Kaplan PW. Epilepsy and obsessive-compulsive disorder. Dialogues Clin Neurosci 2010; 12: 241-248.

Ertekin BA, Kulaksizoglu IB, Ertekin E, Gurses C, Bebek N, Gokyigit A, Baykan B. A comparative study of obsessive– compulsive disorder and other psychiatric comorbidities in patients with temporal lobe epilepsy and idiopathic generalized epilepsy. Epilepsy Behav 2009; 14:634-639. [CrossRef]

Wang HR, Woo YS, Bahk WM. Potential role of anticonvulsants in the treatment of obsessive–compulsive and related disorders. Psychiatry Clin Neurosci 2014; 68:723-732. [CrossRef]

Oflaz S. Kulaksizoglu IB. Psychiatric diagnosis and treatment principles in neurological diseases. Update in Psychiatry 2012; 1:1-15.

Sherer M, Padilla S. A case of obsessiveness induced by levetiracetam in a patient with epilepsy, intellectual disability and pervasive developmental disorder. Mental Health Aspects of Developmental Disabilities 2008; 11:22-26.

Koopowitz LE, Berk M. Response of obsessive compulsive disorder to carbamazepine in two patients with comorbid epilepsy. Ann Clin Psychiatry 1997; 9:171-173. [CrossRef]

da Rocha FF, Bamberg TO, Lage NV, Correa H, Teixeira AL. Obsessive–compulsive disorder secondary to temporal lobe epilepsy with response to carbamazepine treatment. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33:568-569. [CrossRef]