First episode psychotic disorder possibly associated with acetazolamide in a male adolescent with congenital glaucoma
Primer konjenital glokom doğumda görülen nadir bir oftalmolojik hastalıktır ve körlüğün %0.01-0.04den sorumludur. Bir karbonik anhidraz inhibitörü olan asetazolamid glokom ve akut glokom krizlerinde kullanılan tıbbi tedavi alternatiflerinden biridir. Karbonik anhidraz inhibitörleri glokom tedavisi, diüretik etki, migren ve epilepsi tedavisi için kullanılan bir tür ilaç alt sınıfını kapsar. Asetazolamid dışındaki karbonik anhidraz inhibitörleri (topiramat, lakozamid, methazolamid) daha önce psikotik bozukluklarla ilişkilendirilmişlerdir. Bu olgu sunumunda konjenital glokoma bağlı körlüğü olan bir erkek ergende asetazolamidle tetiklenmiş olabilecek bir psikotik bozukluk sunulacaktır.
Konjenital glokomu olan bir erkek ergende asetazolamid ile ilişkili olabilecek ilk atak psikotik epizod
Primer congenital glaucoma is an uncommon ophthalmological disease manifesting at birth and accounting for 0.01-0.04% of total blindness. Acetozalamide, a carbonic anhydrase inhibitor is one of the options in the medical treatment of glaucoma and acute glaucoma crises. Carbonic anhydrase inhibitors are a class of pharmaceuticals, which are being used as anti-glaucoma and diuretic agent and for their anti-migraine and antiepileptic actions. Carbonic anhydrase inhibitors (topiramate, lacosamide, methazolamide) other than acetozalamide have been associated with psychotic disorders. Psychotic disorder possibly induced by acetazolamide in a male adolescent with blindness due to congenital glaucoma is going to be presented in this case report.
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- 1. Mandal AK, Chakrabarti D. Update on congenital glaucoma. Indian J Ophthalmol 2011; 59(Suppl.):148-157.
- 2. Munsch T, Pape HC. Upregulation of the hyperpolarization- activated cation current in rat thalamic relay neurons by acetazolamide. J Physiol 1999; 519:505-514.
- 3. Landgraf S, Osterheider M. To see or not to see: that is the question. The Protection-Against-Schizophrenia (PaSZ) model: evidence from congenital blindness and visuo-cognitive aberrations. Front Psychol 2013; 4:352.
- 4. Sanders GS, Platek SM, Gallup GG. No blind schizophrenics: are NMDA-receptor dynamics involved ? Behav Brain Sci 2003; 26:103-104.
- 5. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30:239-245.
- 6. Inoue H, Hazama H, Hamazoe K, Ichikawa M, Omura F, Fukuma E, Inoue K, Umezawa Y. Antipsychotic and prophylactic effects of acetazolamide (Diamox) on atypical psychosis. Folia Psychiatr Neurol Jpn 1984; 38:425-436.
- 7. Koch HJ, Sykora A, Hausn P. [Off-label use of acetazolamide in a patient with familial hemiplegic migraine and concomitant psychotic episodes]. Psychiatr Prax 2010; 37:148-151.
- 8. Chatzistefanidis D, Karvouni E, Kyritsis AP, Markoula S. First case of lacosamide-induced psychosis. Clin Neuropharmacol 2013; 36:27-28.
- 9. Cyr M, Laizure SC, daCunha CM. Methazolamide-induced delirium. Pharmacotherapy 1997; 17:387-389.
- 10. Singh T. Topiramate and psychosis. Psychiatry (Edgmont) 2006; 3:10-17.