Esra ÖZKARA, Sermin ÖZKAL, İlknur Bilkay GÖRKEM, Meral KOYUNCUOĞLU, Uğur SAYGILI, Turhan USLU, Oktay ERTEN

Servikal karsinomlarda anjiogenez, proliferatif aktivite ve epidermal growth faktör reseptör ekspresyonu

Amaç: Servikal karsinomlu hastalarda evre ve tümör derecesi dışında başka prognostik faktörler de önemli rol oynamaktadır. Proliferatif aktivite, anjiogenez ve epidermal growth faktör reseptör (EGFR) ekspresyonu biyolojik davranışı belirleyebilir. Gereç ve yöntem: Servikal karsinomlu 44 hasta histopatolojik prognostik para-metreler açısından değerlendirildi ve Ki-67, epidermal growth faktör reseptör ve anjiogenezin stereolojik değerlendirmesi için CD-31 antijenleri immünhistokimyasal olarak uygulandı. Bulgular: Olguların evre, derece ve histolojik tipleri arasında bir ilişki saptanmadı. Derece ile proliferatif aktivite ve anjiogenez (NVES= Number of Vessels) arasında güçlü bir korelasyon saptandı. Ancak EGFR ekspresyonu ile diğer parametreler arasında (evre, derece, histolojik tip, proliferatif aktivite ve anjiogenez) bir ilişki bulunmadı. Sonuç: Bu çalışmada derece ile proliferatif aktivite arasında güçlü bir ilişki saptandı. Bu da proliferatif aktivitenin derece ile birlikte kullanılabilecek uygun bir prognostik parametre olabileceğini düşündürdü. Ayrıca anjiogenezin de servikal karsinomlarda tümör agresivitesini gösterebileceği dikkati çekti.

Anahtar Kelimeler:

Antijenler, CD31, Epidermal büyüme faktörü, İmmünohistokimya, Ki-67 antijeni, Serviks neoplazmları, Anjiogenez indükleyen ajanlar

Angiogenesis, proliferative activity and epidermal growth factor receptor expression in cervical carcinomas

Objective: Prognostic parameters other than stage and grade are also playing important roles in. patients with cervical carcinoma. Proliferative activity, angogenesis and epidermal growth factor receptor (EGFR) expression may predict the biologic aggressiveness. Materials and method: Fourty-four patients with cervical carcinoma were evaluated for histopathological prognostic parameters and Ki-67 immunostaining, CD-31 for stereological assessment of angiogenesis and epidermal growth factor expression were performed. Results: There was no correlation between stage, grade and histologie typing. There was a significant relation between grade and proliferative activity and angiogenesis. No relation was found between EGFR expression and the other parameters (stage, grade, histologie typing, proliferative activity and angiogenesis). Conclusions: In this study, we found significant correlation between grade and proliferative activity. So proliferative activity is a useful prognostic parameter that can be evaluated with histologie grade. Also angiogenesis might indicate tumour aggressiveness in servical carcinomas.

Keywords:

Antigens, CD31, Epidermal Growth Factor, Immunohistochemistry, Ki-67 Antigen, Cervix Neoplasms, Angiogenesis Inducing Agents,

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