Özgür ÖZKUL, M. Erdal SAK, Filiz ÖZKUL, Tunç Melike KILIÇKAP, Ahmet YALINKAYA

Uterin leiomiyomlu kadınlarda klinik ve laboratuar özellikler

Bu çalışmada uterin leiomiyomu olan ve olmayan kadınlarda klinik ve laboratuar bulgularının karşılaştırılması amaçlandı. Leiomiyoma’lı 82 hasta çalışma grubunu, leiomiyoması olmayan 42 sağlıklı kadın kontrol grubunu oluşturdu. Olguların yaş, gravida, parite, kan grupları, menstrüel siklus düzeni, başvuru yakınmaları, fertilite durumları, ultrasonografik bulguları, yapılan cerrahi operasyonlar ve tiroid fonksiyon testleri incelendi. Hasta grubu ile kontrol grubu arasında kan grupları dağılımı, parite ve tiroid hormon test sonuçları bakımından istatistiksel olarak anlamlı farklılık yoktu (P>0.05). Hasta ve kontrol grubu arasında kliniğe başvuru şikayetleri bakımından ise istatistiksel olarak anlamlı fark bulundu (p

Clinical and laboratory characteristics of women with uterine leiomiyoma

The aim of this study was to compare clinical and laboratory findings of women with or without uterine leiomyoma. Study group consisted of 82 women with uterine leiomyoma and the control group comprised 42 healthy women. Women’s age, gravity, parity, blood groups, pattern of menstrual cycles, complaints at presentation, fertility, ultrasonographical findings, surgical operations and thyroid function tests were evaluated. There were no significant differences in blood group distribution, gravity, parity and thyroid function test results between the patients and the control subjects (P>0.05). A significant difference was found in the complaints at presentation between two groups (P<0.001). Mentrual cycles irregularity was more frequently found in the patients compared with the controls (57.3% vs. 42.9%, respectively, P=0.009). Although no infertile woman was found in the control group, 8.5% of patients were found to have infertility. The sensitivity of ultrasonography was found to be 97.6%. Except for the existence of higher infertility rate and the menstrual cycles irregularities, no significant difference was found in the clinical and laboratory findings between women with or without uterine leiomyoma. Therefore, physical examination and imaging methods are remained as the most important diagnostic tools for uterine leiomyoma.

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1. Stovall DW. Clinical symptomatology of uterine leiomyomas. Clin Obstet Gynecol 2001;44:364-71.
2. Buttram VC, Reiter RC. Uterine leiomiyomata: Etiology, symptomatology and management. Fertil Steril 1981;36:422-45.
3. Cramer SF, Patel A. The frequency of uterine leiomyomas. Am J Clin Pathol 1990;94:435-8.
4. Marshall LM, Spiegelmen D, Barbieri RL, et al. Variation in the incidence of uterine leiomyoma among premenopausal women by age and race. Obstet Gynecol 1997;90:967-73.
5. Lange R, Meinen K. Diagnosis of thyroid function in uterine myomatosis. Zentralbl Gynakol. 1989;111:47-52.
6. Faerstein E, Szklo M, Rosenshein NB. Risk factors for uterine leiomyoma: a practice-based case-control study. I. African –American heritage, reproductive history, body size, and smoking. Am J Epidemiol 2001;153:1-10.
7. Parazzini F, Negri E, La Vecchia C, et al. Reproductive factors and risk of uterine fibroids. Epidemiology 1996;7:440-2.
8. Marshall LM, Spiegelmen D, Goldman MB, et al. A prospective study of reproductive factors and oral contaceptive use in relation to the risk of uterine leiomiyomata. Fertil Steril 1998;70:432-9.
9. Schwartz SM. Epidemiology of uterine leiomiyomata. Clin Obstet Gynecol 2001;44:316-26.
10. Clevenger-Hoeft M, Syrop CH, Stovall DW, et al. Sonohysterography in premenopausal women with and without abnormal bleeding. Obstet Gynecol 1999;94:516-20.
11. Dubuisson J-B, Chapron C, Chalet X, et al. Fertility after laparoscopic myomectomy of large intramural myomas: preliminary results. Hum Reprod 1996;11:518–22.
12. Ubaldi F, Tournaye H, Camus M, et al. Fertility after hysteroscopic myomectomy. Hum Reprod Update 1995;1:81-90.
13. Farhi J, Ashkenazi J, Feldberg D, et al. Effects of uterine leiomyomata on the results of in-vitro fertilization treatment. Hum Reprod 1995;10:2576-8.
14. Buttram VC, Reiter RC. Uterine leiomyomata: Etiology, symptomatology and management. Fertil Steril 1981;36:422-45.