Şizofreni Hastalarında Serum Büyüme Durdurucu Spesifik Protein 6 (Gas-6) Düzeyleri
Amaç: Çalışmamızda atak ve remisyon durumunda olan şizofreni hastaları ile kontrol grubunun serum büyüme durdurucu spesifik protein 6 (GAS-6) düzeylerini ölçerek bu gruplar arasında bir farklılık olup olmadığını araştırdık. Yöntemler: Çalışmamıza İstanbul Üniversitesi Cerrah- paşa Tıp Fakültesi Ruh Sağlığı ve Hastalıkları Anabilim Dalı servisinde yatan; yapılan psikiyatrik muayenesinde DSM-IV-TR tanı kriterlerine göre ş izofreni tanısı konmuş hastalar (N=22) dahil edilmiştir. Hastaların klinik değer- lendirilmeleri psikotik atak ile hastaneye yatırıldığında ve remisyon esnasında Pozitif ve Negatif Sendrom Ölçeği (PANSS) ve Klinik Global İ zlenim Ölçeği (CGI-S) uygu- lanarak yapıldı. Hastaların psikotik atak esnasındaki ve remisyon sırasındaki serum GAS-6 düzeyleri sağlıklı kontrol grubunun düzeyleri ile karşılaştırıldı. Serum GAS- 6 analizleri ticari ELİZA kitleri ile yapılmıştır. Bulgular: Akut psikotik dönem ve remisyon döneminde- ki şizofreni hastalarının ve kontrol grubundaki kişilerin GAS-6 değerleri analiz edildiğinde bu ü ç grup arasında anlamlı bir fark bulunamamıştır. Serum GAS-6 düzeyleri ile PANSS ve CGI-S değerleri arasında herhangi bir kore- lasyon bulunmadığı görülmüştür. Sonuç: GAS-6 ve şizofreni arasındaki ilişkinin daha net olarak ortaya konulabilmesi için antipsikotik ve diğer ilaç kullanımlarının göz önünde bulundurulduğu daha fazla kişinin dahil edildiği kapsamlı çalışmaların yapılmasına ihtiyaç duyulmaktadır
Serum Growth Arrest Speci fic Protein 6 (Gas-6) Levels in Patients with Schizophrenia
Objective: We have investigated serum growth ar- rest-specific protein 6 (GAS-6) levels from patients with schizophrenia divided into acute phase remission phases as well as control group. Methods: This study was conducted in Psychiatry De- partment of Istanbul University Cerrahpasa Medical Fac- ulty. The patients who were diagnosed with schizophrenia after regular psychiatric examination according to DSM- IV criteria (n=22) as well as control subjects were includ- ed in the study. Schizophrenia patients with acute phase and remission phase were evaluated by Positive and Negative Syndrome Scale (PANSS) and Clinical global Impression Scale (CGI-S). The serum GAS-6 levels of schizophrenia patients during acute phase and remission phase were compared with the serum GAS-6 levels of healthy controls. Serum GAS-6 levels were measured by commercial ELISA kits. Results: No difference was found in serum GAS-6 levels among the three groups; schizophrenia with acute phase, schizophrenia with remission phase, and controls. There were no correlations between serum GAS-6 levels and PANSS and CGI scores. Conclusion: To reach a definitive data and better in- terpretation about the relationship between GAS-6 and schizophrenia, future studies with larger groups of pa- tients with schizophrenia subdivided by drug naïve and treated with antipsychotics/other treatment modalities and controls are needed.
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