Abdulsamet TANİK, FATİH DEMİRCİ, M. Sinan DOĞAN, ARZUM GÜLER DOĞRU

Kronik obstrüktif akciğer hastalığı ve periodontal hastalık ilişkisi

Kronik obstrüktif akciğer hastalığı (KOAH) morbiditesi ve mortalitesi yüksek ve artmakta olan bir hastalıktır. Sigara tüketimine bağlı olarak KOAH tüm dünyada özellikle gelişmekte olan ülkelerde giderek artan bir salgın hastalık haline gelmektedir. Kırk yaşın üstünde, topluma katkıda bulunan erişkin nüfusu etkilemektedir. KOAH zararlı gaz ve partiküllere, özellikle sigara dumanına karşı oluşmuş akciğerlerde hava yollarını, interstisyum ve damar yatağını etkileyen anormal inflamatuvar cevapla karakterize sistemik bir hastalıktır. Birçok çalışmada, KOAH gibi sistemik durumlar periodontitis için bir risk faktörü olduğu saptanmıştır. Bakterilerle yapılan birçok çalışmada, akciğer enfeksiyonu yapan mikroorganizmalar ile oral kavitede yaşayan mikroorganizmanın aynı olduğu ispatlanmıştır. Bu nedenle bu konu ile ilgili, daha uzun süreli, geniş popülasyonlar üzerinde yapılan, klinik mikrobiyolojik ve epidemiyolojik çalışmalara ihtiyaç vardır.

Association between chronic obstructive pulmonary disease and p eriodontal disease

Chronic Obstructive Pulmonary Disease (COPD) morbidity and mortality is high and increasing levels of a disease. COPD is becoming a growing epidemic due to smoking consumption especially in developing countries all over the world. Above the age of forty, affects adult population contributing to the community. COPD is characterized by a progressive, irreversible limitation of airflow associated with an abnormal inflammatory response to noxious particles or gases. It is caused primarily by smoking. In many studies, systemic conditions such as COPD were found to be a risk factor for periodontitis. In many studies with bacteria, has proven to be the same microorganisms in the oral cavity with microorganisms which lung infection. Therefore, on this subject, longer, with the large populations, clinical, microbiological and epidemiological studies are needed.

PDF

___

1. Global Strategy for the Diagnosis, Management, and Prevention of COPD. Available at: www.goldcopd.com. Accessed Apr 2015.
2. Barnes PJ (ed). Chronic Obstructive Pulmonary Disease; Cellular and Molecular Mechanisms. Boca Raton, Taylor&Francis Group, 2005;253-278.
3. MacNee W, ZuWallack RL, Kenann J (eds). Clinical Management of Chronic Obstructive Pulmonary Disease. West Islip, Professional Comm, Inc., 2005;367-384.
4. Scannapieco FA, HoAW. Association of periodontal disease and chronic lung disease Analysis of NHANES III. J Dent Res 1999;78 :1777-1782.
5. Kurtulgan O, Mete A, Uyar M. Kronik obstrüktif akciğer hastalığında ekspiratuar yüksek rezolüsyonlu bilgisayarlı tomografi bulguları ile trakeal indeks ve solunum fonksiyon testleri arasındaki ilişki. Dicle Med J. 2012;39:42-48.
6. Barnes PJ, Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J 2009;33:1165-1185.
7. Yıldırım N. KOAH patogenezi. Ed: S. Umut, N. Yıldırım Kronik Obstrüktif Akciğer Hastalığı (KOAH). Ed. İstanbul: Turgut yayıncılık; 2005:41-58.
8. Mattes, Joerg, and Peter G. Gibson. The early origins of COPD in severe asthma: the one thing that leads to another or the two things that come together?. Thorax 2014;69:789 790.
9. Rubin Bruce K. Respiratory care year in review 2010: part 1. asthma, COPD, pulmonary function testing, ventilator- associated pneumonia. Respiratory care. 2011;56: 488-502.
10. Herr C. The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer. Respir Res 2011; 12: 31.
11. Pride N. Smoking, allergy and airways obstruction: revival of the Duck hypothesis. Clin Allergy 1986;16:3-6.
12. Szafranski W, Cukier A, Ramirez A. et al. Effıcacy and safety of budesonide/formoterol in the management of chronic obstructive pulmonary disease. Eur Respir J 2003;21:74-81.
13. Fletcher C, Peto R. The natural history of chronic airflow obstruction. Br Med J 1977;1:1645-1648.
14. Erdinç E, KOAH atağı. In: Ekim N, Türktaş H. Göğüs Hastalıkları Acilleri. 1st ed. Ankara, Bilimsel Tıp Yayınevi 2000;231-239.
15. Bourbeau J, Nault D, Boryckı E (eds). Comprehensive Management of Chronic Obstructive Pulmonary Disease. London: BC Decker Inc., 2002:73-84.
16. Erden E. Ş, Dokuyucu R, Demirköse M. et al. Kronik obstrüktif akciğer hastalığının akut alevlenme ve stabil dönemlerinde ortalama trombosit hacminin incelenmesi. J Clin Exp Invest 2013;4:483-487.
17. Coulthwaite L, Verran J. Potential pathogenic aspects of denture plaque. British J Biomed Sci 2007;64:180-189.
18. Scannapieco FA. Genco RJ. Association of periodontal infections with atherosclerotic and pulmonary disaeses. J Periodontal Res 1999;34:340-345.
19. Pauwels RA, Lofdahl CG, Laitinen LA. et al. Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking: European Respiratory Society Study on Chronic Obstructive Pulmoary Disease. N Engl J Med 1999;1948- 1953.
20. Scannapieco FA. Role of oral bacteria in respiratory infection. J Periodontal.1999;70:793-802.
21. Scannapieco FA. Potential association between chronic respitory disease : Analysis of National Health and Nutrition Examination Survey III. J Periodontal 2001;72:50-56.
22. Scannapieco FA, Papandonatos GD, Dunford RG. Associations between oral conditions and respiratory disease in a national sample survey population. Ann Periodontal 1999;3:251-256.
23. Finegold SM. Aspiration pnuemonia. Rev Infect Dis 1991;13:737-742.
24. Morris JF, Sewell DL. Necrotizing pnuemonia caused by mixed infection with Actinobacillus actinomycetemcomitans and Actinomyces israeli: Case report and review. Clin Infect Dis 1994;18.450-452.
25. Scannapieco FA, Bush RB, Paju S. Associations between periodontal disease and risk for nasocomial bacterial pnuemonia and chronic obtrüctive pulmonary disease. A sytemic review. Ann Periodontal 2003;8:54-69.
26. Murphy TF, Sethi S. Bacterial infection in chronic obstructive pulmonary disease. Am Rev Respir Dis.1992;146:1067- 1018.
27. Widmer, Richard P. Oral health of children with respiratory diseases. Paediatric Resp Rev 2010;11:226-232.
28. Teng YT, Taylor GW, Scannapieco F. et al. Periodontal health and systemic disorder. J Can Dent Assoc 2002;68:188-192.
29. Wilson M, Reddi K, Henderson B. Cytokine-inducing components of periodontopathogenic bacteria. J Periodontal Res 1996;31:393-407.
30. Scannapieco FA, Wang B, Shiau HJ. Oral bacteria and respiratory infections : Effects on respiratory pathogen adhesion and epitheial cell proinlammantory cytokine production. Ann Periodontal 2001;6:78-86.
31. Tuncer, B. Medikal sorunlu bireylerde ortodontik yaklaşımlar. Atatürk Üniv Diş Hek Fak Derg 2005;15:40-51.