Erdal KAYDU, İbrahim ERBAĞCI, Seydi OKUMUŞ, Ümit AKSOY

İlerleyici Keratokonus Olgularında Riboflavin/UV-A ile Korneal Çapraz Bağlama Tedavisinin Sonuçları

Amaç: Keratokonus kliniğinde ilerleme saptanan olgular- da, UV-A/riboflavin ile korneal kollajen çapraz bağlama yönteminin sonuçlarının değerlendirilmesi. Yöntemler: İlerleyici keratokonusu olan 30 olgunun (16 kadın, 14 erkek) 47 gözü çalışmaya dahil edildi. Tüm ol- guların uygulama öncesi ve sonrasında, düzeltilmemiş ve düzeltilmiş en iyi görme keskinleri, biyomikroskopik bul- guları, göz içi basınç ölçümleri, fundus bulguları, pakimet- ri değerleri ve kornea topografi parametreleri kaydedildi. Bulgular: Olguların ortalama yaşı 18,3 yıl (8-31) ve orta- lama takip süresi 7±2,4 ay (3-12) idi. Uygulama sonrasın- daki takipler sonucunda ortalama K1, K2, Kav, sferik ve silindirik değerlerde sırasıyla; 0,77 diyoptri (D), 0,85 D, 0,80 D, 0,50 D ve 0,74 D azalma saptandı (p

The Results of Cross-Linking With Riboflavin/UV-A in Patients With Progressive Keratoconus

Objective: To evaluate the results of corneal cross-link- ing with UV-A/riboflavin in patients with progressive kera- toconus. Methods: Forty-seven eyes of 30 patients with progres- sive keratoconus (16 female, 14 male) were included in the study. Uncorrected and the best corrected distance visual acuities, biomicroscopic findings, intraocular pres- sure measurements, fundoscopic findings, pachymetric measurements and corneal topography parameters were recorded for each patient. Results: The mean age of the patients was 18.3±5.34 (range: 8-31) years and the mean follow-up duration was 7±2.4 (range: 3-12) months. Following the procedure, the mean decrease in K1, K2, Kav, spherical and cylindri- cal values were 0.77 D, 0.85 D, 0.80 D, 0.50 D and 0.74 D, respectively (p<0.05). There were no cases with de- crease in visual acuity and significant complication during or after the treatment. Conclusion: Cross-linking with riboflavin/UV-A in patients with progressive keratoconus is an effective procedure. In addition, the preservation of visual acuity and not seen a significant complication indicate that a safe metod. How- ever, large prospective randomized controlled studies are needed to evaluate the long-term effects of this treatment.

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