Hacı Mehmet ÇALIŞKAN, Bilal İLANBEY, Duygu ZORLU, Zamir ERTÜRK, Burak ÇELİK, Süleyman ERSOY

Thiol/disülfid homeostazının kronik obstrüktif akciğer hastalığı ile ilişkili mortalitedeki etkisi

Amaç: Bu çalışmada Hiperkapnik solunum yetmezliği (HSY) olan kronik obstrüktif akciğer hastalarındaki mortalite (KOAH) ile thiol/disülfid homeostazisi arasındaki ilişki araştırılmıştır. Gereç ve Yöntem: Bu kesitsel prospektif çalışma, solunum yetmezliği nedeniyle acil servise başvuran 64 hiperkapnik solunum yetmezliği (HSY) hastası ve 40 sağlıklı kontrol dahil olmak üzere toplam 104 kişiden oluşmaktadır. HRF hastaları ayrıca 1 ay sonra mortalite meydana gelenler (n = 14) ve hayatta kalanlar olarak iki alt gruba ayrıldı. Thiol/Disülfid homeostazı, Erel ve Neselioğlu tarafından geliştirilen yeni ve otomatik bir ölçme yöntemi kullanılarak değerlendirildi. Bulgular: Total thiol (TT) ve native thiol (NT) seviyeleri, HSY grubunda kontrol grubuna göre anlamlı derecede daha düşüktü, oysa ortalama disülfid (Ds)/ TT ve Ds / NT değerleri önemli ölçüde daha. Disülfid seviyelerinde ise guruplar arasında önemli bir fark yoktu. Ayrıca Hayatta kalan HRF hastalarının Ds, Ds / TT ve Ds / NT değerleri, ölen HRF hastalarınınkinden önemli ölçüde daha düşüktü. Biz bu makalede Disülfid’in KOAH'da mortalitenin bir göstergesi olabileceğini bulduk (duyarlılık:% 85.7, özgüllük:% 70, EAA: 0.793,% 95 CI: 0.673-0.884, p

The effect of thiol/disulfide homeostasis on chronic obstructive pulmonary disease-related mortality

Purpose: Our study investigates the correlation between thiol/disulfide homeostasis and mortality among chronic obstructive pulmonary disease (COPD) patients with hypercapnic respiratory failure (HRF). Materials and Methods: This cross-sectional prospective study comprises a total of 104 subjects, including 64 HRF patients admitted to the Emergency service due to respiratory failure and 40 healthy controls. HRF patients were further divided into two subgroups as those in whom mortality occured after 1 month (n=14), and those who survied (n=50). Thiol/disulfide homeostasis was evaluated using a novel and automated assay developed by Erel and Neselioglu. Results: The total thiol (TT) and native thiol (NT) levels were significantly lower in the HRF group than the control group, whereas the mean disulfide (Ds)/TT and Ds/NT values were significantly higher. The Ds levels were not significantly different between the groups. On the other hand, Ds, Ds/TT, and Ds/NT values of surviving HRF patients were significantly lower than those of the HRF patients who died. In this article we found that Ds may be an indicator of mortality in COPD (sensitivity: 85.7%, specificity: 70%, AUC: 0.793, 95% CI: 0.673-0.884, p

Keywords:

Emergency service, hypercapnic respiratory failure, oxidative stress, thiol,

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