Volkan GÖKBULUT, Ömer ÖZTÜRK, Meral AKDOĞAN KAYHAN, Mustafa KAPLAN, Sabite KACAR, Hale SÜMER, Püren GÖKBULUT, Derya ARI, Dilara TURAN GÖKÇE

Primer biliyer kolanjit, primer sklerozan kolanjit ve otoimmün hepatit tanısı alan hastalarda özofagus motor fonksiyonlarının değerlendirilmesi

Amaç: Bu çalışmada otoimmün karaciğer hastalıkları ile özofagus motor bozuklukları (EMD) arasındaki ilişkinin incelenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya Primer biliyer kolanjit (PBC), primer sklerozan kolanjit (PSC) ve otoimmün hepatit (AIH) tanısı konan ve hastanemizde takip edilen 63 hasta dahil edildi. Kontrol grubu 33 hastadan oluşturuldu. Çalışmaya dahil edilen tüm katılımcılara üst gastrointestinal endoskopi, özofagus motilite çalışması ve pH metre testleri yapıldı. Bulgular: Çalışmaya dahil edilen 63 hastanın %49.2'sinde EMD, %31,7'sinde pH metrede patoloji saptandı. PBC, PSC ve AIH'li hastaların EMD oranları sırasıyla %50, %63.6 ve %42,9 iken pH metrenin patoloji oranları sırasıyla %25, %54.5 ve %28.6 olarak bulundu. Otoimmün karaciğer hastalığı ile kontrol grubu arasında özofagus motor hastalıkları açısından istatistiksel olarak anlamlı fark bulundu Manometrik inceleme sonucunda otoimmün karaciğer hastalarında kontrol grubuna göre alt özofagus sfinkter dinlenme basıncı anlamlı olarak daha düşüktü Sonuç: Çalışmamız, PBC, PSC ve AIH'li hastalarda EMD'nin yaygın olduğunu ve siroz varlığının EMD gelişimi üzerinde hiçbir etkisi olmadığını ortaya koymaktadır.

Anahtar Kelimeler:

Primer biliyer kolanjit, primer sklerozan kolanjit, otoimmün hepatit, özofagus motilite bozukluğu

Evaluation of esophageal motor functions in patients diagnosed with primary biliary cholangitis, primary sclerosing cholangitis and autoimmune hepatitis

Purpose: The aim of this study was to evaluate the relationship between autoimmune liver diseases and esophageal motor disorders (EMD). Materials and Methods: 63 patients diagnosed with primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) and followed up in our hospital were included in the study. The control group consisted of 33 patients. Upper gastrointestinal endoscopy, esophageal motility study and pH meter tests were performed on all participants. Results: Of the 63 patients included in the study 49.2% of the patients, EMD was detected while 31.7% of them had pathology in the pH meter. The rates of EMD of patients with PBC, PSC and AIH were 50%, 63.6%, and 42.9%, respectively while the pathology rates of the pH meter were found as 25%, 54.5%, and 28.6%, respectively. Statistically significant difference was found between autoimmune liver disease and control group in terms of esophageal motor diseases. As a result of manometric examination, median lower esophageal sphincter resting pressure was significantly lower in autoimmune liver patients compared to the control group. Conclusion: Our study presents that EMD is common in patients with PBC, PSC, and AIH, and that the presence of cirrhosis has no impact on the development of EMD.

Keywords:

primary biliary cholangitis, primary sclerosing cholangitis, autoimmune hepatitis, esophageal motility disorder,

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