Tuğba GÜRBÜZ, Oya GÖKMEN, Nur DOKUZEYLÜL GÜNGÖR

Polikistik over sendromu bulunan kadınlarda glikoz potasyum oranının tanısal değerinin insülin ile karşılaştırılması

Amaç: Polikistik over sendromu (PKOS), üreme çağındaki kadınların %12-23'ini etkileyen en yaygın endokrin bozukluktur. Bu çalışmada, PKOS’lu hastalarda serum Glikoz Potasyum (Glu/K+) oranının tanısal değeri olup olmadığı araştırıldı. Gereç ve Yöntem: Bu araştırma, hasta verileri kullanılarak retrospektif tek merkezli yürütülen bir analiz çalışmasıdır. Çalışma kriterlerine uygun 98 PKOS’lu ile 78 yaş uyumlu kadın kontrol grubu çalışmaya dahil edildi. Serum Glu/K+ oranı, serum açlık Glikozunun serum potasyum düzeylerine bölünmesiyle hesaplandı ve laboratuvar verileri tüm hasta ve kontrol grubu için analiz edildi. Bulgular: İnsülin ile Glu/K+ oranı arasında korelasyon analizinde anlamlı bağıntı tespit edildi. Glu/K+ oranı için ROC eğri altındaki alan insüline yakın şekilde 0,759 bulundu.. ROC analizine göre PKOS tanısı için İnsülin cut-off değeri 81% duyarlılık ve 75% özgüllük değerinde 9,1 olarak tespit edilirken Glu/K+ oranının cut-off değeri 74% duyarlılık ve 71% özgüllük değerinde 21,4 olarak hesaplandı. Sonuç: Sonuçlarımız, serum Glu/K+ oranının PKOS için tanısal özelliklere sahip olan insülin ile pozitif ve yakından ilişkili olduğunu göstermektedir. Serum Glu/K+ oranının PCOS için yararlı bir biyobelirteç olarak kullanılabilecek duyarlılık ve özgüllüğe sahip olduğu tespit ettik.

Comparison of the diagnostic value of glucose-potassium ratio with insulin in women with polycystic ovary syndrome

Purpose: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects 12-23% of women of reproductive age. In this study, it was investigated whether serum Glucose to Potassium (Glu/K+) ratio has a diagnostic value in patients with PCOS. Materials and Methods: This research is a single-center, retrospective analysis study conducted. A PCOS group of 98 patients and 78 age-matched women was included in the study. Serum Glu/K+ was calculated by dividing serum fasting Glucose by serum potassium levels, and laboratory data were analyzed for the whole patient and control group. Results: A significant correlation was found in the correlation analysis between insulin and Glu/K+ ratio. The area under the ROC curve for the Glu/K+ ratio was found to be 0.775, close to the insulin. According to ROC analysis, Insulin cut-off value was found to be 9.1 with a sensitivity of 81% and a specificity of 75%, while the cut-off value of Glu/K+ ratio was calculated as 21.4 with a sensitivity of 74% and a specificity of 71%. Conclusion: Our results show that the serum Glu/K+ ratio is positive and closely related to insulin, which has diagnostic properties for PCOS. We found that the serum Glu/K+ ratio has sensitivity and specificity that can be used as a useful biomarker for PCOS.

Keywords:

Polycystic Ovary Syndrome, Glucose Potassium Rate, Insulin,

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