Sabri Berkem ÖKTEN, Zehra Nihal DOLGUN, Vedat UGUREL, Koray ELTER

Ovulasyon indüksiyonu ve intrauterin inseminasyon sonrası infertil kadınlarda gebelik hızlarının değerlendirilmesi

Amaç: Bu çalışmada ovulasyon indüksiyonu ve intrauterin inseminasyon sonrası infertil hastalarda bu faktörlerin gebelik oranlarına etkilerini araştırılması amaçlanmıştır.Gereç ve Yöntem: Çalışma retrospektif olarak incelendi ve açıklanamayan infertilite, erkek faktörü ve anovülasyonu olan 201 infertil hastanın laboratuvar sonuçları ve raporları incelendi. Kadınlar gonadotropin veya klomifen sitrat olarak kullanılan ovulasyon uyarıcı maddeye göre iki gruba ayrıldı. Tüm katılımcılardan alınan semen örnekleri değerlendirildi.Bulgular: Açıklanamayan infertilite 239 siklus (77.9%), ovulatör disfonksiyonda 39 (12.7%) ve erkek faktör (9.4%) gruplarında 29 siklus vardı. İnfertilite tipine göre siklus başına klinik gebelik oranları açıklanamayan infertilite için 18.4% (n:44), ovulasyon disfonksiyonu için 17.9% (n:7), erkek faktör için13.8% (n:4) olarak bulundu. Regresyon analizlerinde hCG uygulamasının yapıldığı gün folikül (çap>10 mm) sayısı ve insemine toplam hareketli sperm sayısı (ITHSS) gebelik oranını bağımsız olarak etkiledi. ITHSS eğrisi altındaki alan değeri (0.63) 0.5'ten anlamlı olarak farklıydı. Sonuç: hCG uygulamasının yapıldığı gün folikül sayısının ve ITHSS'nin gebelik oranını bağımsız olarak etkilediğini göstermiştir. Ek olarak, kabul edilebilir başarılı bir gebelik oranına sahip uygun durumlarda intrauterin inseminasyon yöntemi denenmelidir.

Anahtar Kelimeler:

Gebelik Hızı, Ovulasyon İndüksiyonu, İnfertilite

Evaluation of pregnancy rates in infertile women after application of ovulation induction and intrauterine insemination

Purpose: The aim of this studywas to investigate the effects of these factors on pregnancy rates in infertile patients following ovulation induction and intrauterine insemination. Materials and Methods: The study was performed retrospectively that investigated examination reports and laboratory results of 201 infertile patients with unexplained infertility, male factor and anovulation. Women were subdivided into two groups according to the ovary-stimulating agent used as gonadotropin or clomiphene citrate. A semen sample was obtained from all men participants. Results: There were 239 cycles of unexplained infertility (77.9%), 39 cycles in ovulatory dysfunction (12.7%) and 29 cycles in male factor (9.4%) groups. The clinical pregnancy rates per cycle according to infertility type were found as 18.4% (n:44) for unexplained infertility, 17.9% (n:7) for ovulatory dysfunction and 13.8% (n:4) for malefactor. In regression analyses, follicle (diameter>10mm) count on the day of hCG administration and inseminated total motile sperm count (ITMSC) were independently affected pregnancy rate. ITMSC area value under the curve (0.63) was significantly different from 0.5. Conclusion: Follicle count on the day of hCG administration and ITMSC independently affect the pregnancy rate. Additionally, the intrauterine insemination method should be attempted in appropriate cases that have an acceptable successful pregnancy rate.

Keywords:

Pregnancy Rate, Infertility, Ovulation Induction,

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