Şengül ŞAHİN, Özlem AYBASTI, Gülçin ELBOĞA, Abdurrahman ALTINDAĞ, Lut TAMAM

Major depresyonda elektrokonvulsif terapinin oksidatif metabolizma üzerine etkisi

Amaç: Elektrokonvulsif terapinin (EKT) majör depresyonda etkinliği bilinmektedir. Bu çalışmada majör depresyonda EKT’nin total antioksidan seviye, total oksidan seviye, oksidatif stres indeksi üzerindeki etkilerine bakılmıştır.Gereç ve Yöntem: DSM-IV’e göre majör depresyon tanısı konulan 23 hasta ve 22 sağlıklı kontrol çalışmaya alındı. Hastalara sosyodemografik ve klinik bilgilendirme formu uygulandı. Hasta ve kontrollerden venöz kan örnekleri alındı. serum total antioksidan, total oksidan düzeylerine bakıldı. Bulgular: Elektrokonvulzif terapi uygulaması öncesi hasta grubunda antioksidan seviye kontrol grubuna kıyasla daha düşük bulunmuştur. Hasta grubunda EKT uygulaması sonrası antioksidan seviye elektrokonvulzif terapi öncesine göre anlamlı düzeyde artmıştır. Elektrokonvulzif terapi uygulaması sonrası antioksidan seviye kontrol grubu ile kıyaslandığında anlamlı farklılık kalmamıştır. EKT öncesi ve sonrasında bakılan total oksidan seviye ve oksidatif stres indeksi açısından hasta ve kontrol grupları arasında anlamlı farklılık saptanmamıştır.Sonuç: EKT uygulaması sonrasında hastalarda total antioksidan seviye düzeyinin artması, EKT’nin majör depresyon hastalarında antioksidan seviye artışına neden olduğunu düşündürmektedir.

Anahtar Kelimeler:

Major depresyon, elektrokonvülsif terapi, oksidatif stres, toplam antioksidan seviye

Effect of electroconvulsive therapy on oxidative metabolism in major depressive disorder

Purpose: Electroconvulsive therapy (ECT) has been shown to be effective for majör depressive disorder. This study aimed to evaluate the association between ECT and the effects of ECT on total antioxidant level, total oxidant level, oxidative stress index in major depression.Material and Methods: The study group consisted of 23 inpatients with majör depressive disorder defined by DSM-IV criteria and 22 healty volunteers. Socio-demographic and clinical information were collected using structured questionnaire. Venous blood samples were taken from patients and controls. The biochemical parameters analyzed were serum total antioxidant level, total oxidant level.Results: Total antioxidant level was lower in the majör depressive disorder group compared with those of the controls before ECT. Total antioxidant levels were significantly increased with electrocunvulsive therapy in patient group. There was no significant difference for total antioxidant levels after ECT. There was no significant difference between patient and control groups in terms of total oxidant level and oxidative stress index before and after ECT.Conclusion: The results suggest that ECT leads to an increase in antioxidant levels in patients with majör depressive disorder.

Keywords:

Major depression, electroconvulsive therapy, oxidative stress, total antioxidant level,

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