Ahmet ADIGÜZEL, Sibel ÇIPLAK, Ünal ÖZTÜRK

Lipid düzeylerinin ve LDL-C/HDL-C oranının intraserebral hemorajilerde olası bir risk belirteci olarak değerlendirilmesi

Amaç: Bu çalışmanın amacı lipid parametrelerinin tek tek ve düşük dansiteli lipoprotein kolesterol/yüksek dansiteli lipoprotein kolesterol (LDL-C/HDL-C) oranına bakarak intraserebral hemoraji (ISH) için bir olası risk belirteci olarak kullanılabilirliğini analiz etmektir. Gereç ve Yöntem: Çok merkezli, retrospektif vaka-kontrol çalışmasıdır. İntraserebral hemorajisi olan 226 hasta ve 226 kontrol çalışmaya dahil edilmiştir. İntraserebral hemorajisi beyin bilgisayarlı tomografide teyit edilen ve altta yatan vasküler, travmatik ve metabolik bir neden bulunamayan hastalardan 12 saatlik açlık sonrası lipid parametreleri değerlendirildi. Bulgular: Yaptığımız araştırmada LDL-C ve total kolesterol (TC) ortalaması hasta ve kontrol gruplarında anlamlı farklılık göstermedi. Hasta gruplarında HDL-C ortalamaları anlamlı düzeyde düşükken, trigliserid (TG) düzeyleri yüksekti. Hasta ve kontrol grupları arasında LDL-C/HDL-C oranı sırasıyla 2,65 ± 1,10 ve 2,94 ± 1.13 (p=0,006), TG/HDL-C oranı 3,60 ± 2,72 ve 4,47 ± 3,25 (p=0,002) son olarak TC/HDL-C oranı 4,37 ± 1,49 ve 4,83 ± 1,56 (p=0,002) tespit edildi. Sonuç: Artan TG ve azalan HDL-C düzeylerinin ISH ile ilişkili olduğu görülmüştür. Bununla beraber LDL-C, TC ve TG’nin HDL-C ile arasındaki oranlarının hasta grubunda daha düşük olduğu analiz edildi. Bu nedenle hemoraji riskini belirlemede bu lipid oranlarının daha net ve anlamlı sonuçlar verdiğini önerebiliriz.

Anahtar Kelimeler:

LDL-C/HDL-C ratio, triglyceride/HDL-C ratio, hemorrhagic stroke, cholesterol, cerebrovascular disease

Evaluation of lipid levels and LDL-C/HDL-C ratio as possible risk markers of intracerebral hemorrhage

Purpose: The aim of this study is to analyze the utility of lipid parameters individually and the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio as a possible risk marker for intracerebral hemorrhages (ICH). Materials and Methods: This was a multicenter, retrospective case-control study that included 226 patients with ICH and 226 controls. Lipid parameters were evaluated after 12 h of fasting in patients whose ICH was confirmed by brain computed tomography, and no underlying vascular, traumatic, or metabolic cause could be found. Results: The mean LDL-C levels and mean total cholesterol (TC) levels did not differ in in the patient and control groups. The mean HDL-C levels in the patient groups were significantly lower whereas triglyceride (TG) levels were significantly higher. In the patient and control groups, LDL-C/HDL-C ratio was 2.65±1.10 and 2.94±1.13 (p=0.006), TG/HDL-C ratio was 3.60±2.72 and 4.47±3.25 (p=0.002), and TC/HDL-C ratio was 4.37±1.49 and 4.83 ± 1.56 (p=0.002), respectively. Conclusion: Increased TG and decreased HDL-C levels were found to be associated with ICHs. However LDL-C/HDL-C, TC/HDL-C, and TG/HDL-C ratios were low in the patient group. Therefore, we can conclude that these lipid ratios give clearer and more significant results in determining the risk of hemorrhage.

Keywords:

LDL-C/HDL-C ratio, triglyceride/HDL-C ratio, hemorrhagic stroke, cholesterol, cerebrovascular disease,

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