Özgür Kartal, Şevket Arslan, Mustafa Güleç, Ahmet Zafer Çalışkaner, Abdullah Baysan, Nail Ersöz, Uğur Musabak, Osman Şener

Herediter anjioödemli hastalarda karın ağrısının tek nedeni herediter anjioödem olmayabilir!

Herediter anjioödemin temel klinik presentasyonlarından birisi karın ağrısıdır. Danazol herediter anjioödem hastalarında uzun yıllar yaygın olarak kullanılmış olan bir ilaçtır. Burada nihai tanıları kolon karsinomu olan danazol tedavisi altında karın ağrısı olan iki herediter anjioödem hastası sunulmuştur. Bu makalede 2 konu vurgulanmıştır. Birincisi; herediter anjioödem hastalarında ‘’karın ağrısı’’ ayırıcı tanısının, herediter anjioödem tanısı mevcut olsa bile yapılması gereken bir semptom olma özelliğini koruduğunu vurgulamak; ikincisi ise uzun süreli uygulanan danazol tedavisinin maligniteler gibi olası bir advers etkisini ortaya koymaktır.

Anahtar Kelimeler:

Herediter anjioödem, danazol, kolon kanseri, karın ağrısı, ayırıcı tanı

Hereditary angioedema may not be the only cause of abdominal pain in patients with hereditary angioedema!

Abdominal pain is one of the basic clinical presentations of the hereditary angioedema and danazol is a common medicine which has been used for long years in patients with hereditary angioedema. We present two hereditary angioedema patients with abdominal pain albeit under danazol treatment, whose final diagnoses was colon carcinoma. There are two consequences in this article which shall be insisted on: First; in patients with hereditary angioedema, the differential diagnosis of “abdominal pain” is always important even though hereditary angioedema diagnosis exists. And the second; It can be hardy speculated that long term danazol treatment may cause different malignancies.

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