Kranyumda ağrılı şişlik ile gelen aspergillus osteomiyelit olgusu

Aspergillozis, immun sistemi sağlam bireylerde görülmesi çok nadir, yüksek mortalite ve morbidite ile seyreden bir mantar enfeksiyonudur. Aspergillus osteomyeliti sıklıkla immün baskılanmış olgularda görülen bir klinik durumdur. Ancak öncesinde sağlıklı olan bireylerde saptanması durumunda olgular altta yatan immün yetmezlikler açısından değerlendirilmelidir. Bu makalede kranyumda ağrılı şişlik yakınması ile gelen öncesinde sağlıklı, kronik granülomatöz hastalık ve aspergillus osteomiyelit olan bir olgu sunulmaktadır. (J Pediatr Inf 2012; 6: 106-8)

Osteomyelitis presenting with cranial swelling

Aspergillosis is a rare fungal infection with high morbidity and mortality. Aspergillus osteomyelitis occurs rarely and classically in children with immune supressive disease. If there is no history of immune supression, it is necessary to examine the predisposing factors. In this article, we present a healthy patient with pain in the cranium diagnosed with chronic granulomatous disease and aspergillus osteomyelits. (J Pediatr Inf 2012; 6: 106-8)

Kaynakça

1. İnce E, Çocuklarda İnvaziv Mantar Enfeksiyonlarının Klinik Belirtileri. J Pediatr Inf 2007; 1(Özel Sayı 1); 23-8.

2. Ayberkin E, Çiftçi E. Çocuklarda Aspergillus Enfeksiyonları. J Pediatr Inf 2009; 3: 118-25.

3. Walsh J T, Anaissie EJ, Denning DW ve ark. Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectous Deseases of America. Clinical Infectuous Deseases 2008; 46: 327-60.

4. Van den Berg JM, van Koppen E, Ahlin A, et al. Chronic Granulomatous Disease: The European Experience. Plos One 2009; 4: 5234.

5. Chang HM, Yu HH, Yang YH, et al. Successful Treatment of Aspergillus flavus Spondylodiscitis With Epidural Abscess in a Patient With Chronic Granulomatous Disease. Pediatr Infect Dis J 2012; 31: 100-1.

6. Segal BH, Romani LR. Invasive Aspergillosis in Chronic Granulomatous Disease. Med Mycol 2009; 47: 282-90.

7. Walsh TJ, Anaissie EJ, Denning DW, et al. Treatment Of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America. Clin Infect Dis 2008; 46: 327-60.

8. Gupta PK, Mahapatra AK, Gaind R, Bhandari S, Musa MM, Lad SD. Aspergillus spinal epidural abscess. Pediatr Neurosurg 2001; 35: 18-23.

9. Tew CW, Han FC, Jureen R, Tey BH. Aspergillus Vertebral Osteomyelitis and Epidural Abscess. Singapore Med J 2009; 50: 151-4.

10. Patiroglu T, Unal E, Yikilmaz A, Koker MY, Ozturk MK. Atypical Presentation of Chronic Granulomatous Disease in an Adolescent Boy With Frontal Lobe Located Aspergillus Abscess Mimicking İntracranial Tumor. Childs Nerv Syst 2010; 26: 149-54.

11. Winkelstein JA, Marino MC, Johnston RB Jr, et al. Chronic Granulomatous Disease. Report on a National Registry Of 368 Patients. Medicine (Baltimore) 2000; 79: 155-69.

12. Dotis J, Roilides E. Osteomyelitis due to Aspergillus Species in Chronic Granulomatous Disease: an Update of the Literature. Mycoses 2011; 6: 686-96.

Kaynak Göster