Çocuklarda Üst Solunum Yolu İnfeksiyonlarında 2006-2008 Dönemi Viral Etiyoloji Araştırması

Amaç: Çocuklarda üst solunum yolu infeksiyonlarının viral etiyolojisinin saptanması ve etkenlerin yıllara göre dağılımının gösterilmesi amaçlandı. Yöntem: Prospektif, klinik bu araştırma İstanbul Üniversitesi İstanbul Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı Polikliniğine 2006-2008 yılları arasında başvuran ve yaşları 1-180 ay olan 380 üst solunum yolu infeksiyonlu vaka ile yürütüldü. Vakaların klinik bulguları kaydedildikten sonra, nazal sürüntü örneği alındı ve 380 örnekte İnfluenza-A, B ve Respiratuar Sinsisyal Virüs araştırıldı. Bulgular: Nazal sürüntülerden virüs izole edebilme oranımız % 23.1’dir. En sık izole edilen virüsler sırasıyla influenza-A % 62.5 ve respiratuar sinsisyal virüs % 28.4 olarak saptandı. İnfluenza A tüm yaş gruplarında en yüksek oranda bulunan virustür. İnfluenza A izolasyon oranı yaşla artmaktadır 0-24 ay arasında % 51.5, 2-5 yaş arasında % 50, > 5 yaşta % 78.1 olarak influenza A virusu izole edildi . Sonuç: Çocuklarda üst solunum yolu infeksiyonlarında viral etiyoloji % 23.1 oranındadır ve en sık etken influenza tip A’dır

The Investigation of Viral Etiology in Children with Upper Respiratory Tract Infection Between the Years 2006 and 2008

Objectives: We aimed to detect the viral etiology of upper respiratory tract infections in children and the range of agents through years. Methods: This was a prospective clinical study done in Istanbul Unıversty, Faculty of Medicine. We studied with 380 children with upper respiratory tract infection whose ages were between 1 and 180 months and applied our department of pediatrics in 2006- 2008. After the clinical findings of the cases have been recorded nasal smear sampling was done and in 380 sample we search for influenza A-B and Respiratory syncytial viruses. Results: We isolated virus in 23.1 % percent of nasal smear samples. The most frequent viruses were found as influenza A 62.5 % and respiratory syncytial virus 28.4 % . Influenza A was the most common agent in all age groups. The isolation rate of influenza A was increased as the children get older We isolated influenza A virus in 51.5 % of 0-24 months oldchildren, 50 % of 2-5 years old children and 78.1 % of children older than 5 years . Conclusion: The viral etiology rate of upper respiratory tract infections in children is 23.1 % and the most common agent is influenza A.

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  • Monto AS. Epidemiology of viral respiratory infections. Am Hall CB. Medical progress: respiratory syncytial virus and parainfluenza virus. N Engl J Med 2001; 344:1917-28.
  • Glezen WP, Paredes A, Taber LH. Influenza in children: ralationship to other respiratory agents. JAMA 1980; :1345-9. patient visits and hospitalizations related to influenza in infants and young children. Pediatrics 2004; 113:585-93.
  • Hemming VG. Viral respiratory diseases in children: classifi- cation, etiology, epidemiology, and rik factors. J Pediatr 1994; :513-6.
  • Peters MF, van der Plas SM, Wilbrink B. A case-control study of acute respiratory tract infection in general practice patients in The Netherlands. Clin Infect Dis 2005; 41:490-7.
  • Williams JV. The clinical presentation and outcomes of child- ren infected with newly identified respiratory tract viruses. Infect Dis Clin North Am 2005; 19:569-84.
  • MR. The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children. N Engl J Med ; 342:225-31. Wesseligh S. Comparison of a multiplex revers transcription enzyme hybridization assay with conventional viral culture and immunofluorescense technique for the detection of seven viral respiratory pathogens. J Clin Microbiol 2001; 39:2779
  • Morens MD. Influenza-related mortality. JAMA 2003; :227-9.
  • Grijalva CG, Craig AS, Dupont WD, et al. Estimating inf- luenza hospitalizations among children. Emerg Infect Dis ; 12:103-9. :227-9 and the rates of hospitalization for respiratory disease among infants and young children. N Engl J Med 2000; 342:232-9.
  • Poehling KA, Edwards KM, Weinberg GA, et al. The underrecognized burden of influenza in young children. N Engl J Med 2006; 355:31-40. versus nasopharyngeal aspirate for isolation of respiratory viruses. J Clin Microbiol 2002; 40:4337-9.
  • Wesselingh S. Comparison of a multiplex revers transcription- PCR-enzyme hybridization assay with conventional viral culture and immunofluorescense technique for the detection of seven viral respiratory pathogens. J Clin Microbiol 2001; :2779-83.
  • Influenza and respiratory syncytial virus morbidity among 19 aged group in Yunus Emre Health Center. Turk J Pediatr ; 47:316-22. tory syncytial virus, influenza and parainfluenza viruses to acute respiratory infections in San Luis Potosi, Mexico. Pediatr Infect Dis J 2005; 24:1049-52. BMJ 2006; 332:67. based surveillance for hospitalizations associated with respira- tory syncitial virus, influenza virus, and parainfluenza viruses among young children. Pediatrics 2004; 113:1758-64.
Çocuk Dergisi-Cover
  • ISSN: 1302-9940
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2000
  • Yayıncı: İstanbul Üniversitesi