Gestasyonel Trofoblastik Hastalık Tanısı Alan Olguların Değerlendirilmesi

Giriş ve Amaç: Çalışmamızın amacı, gestasyonel trofoblastik hastalık (GTH) tanısı alan hastalarımızın insidansını, demografik özelliklerini, komplikasyonlarını, takip ve tedavi yaklaşımlarını güncel literatür bilgileriyle tartışılmasıdır. Gereç ve Yöntemler: Kliniğimizde 2005- 2020 tarihleri arasında histopatolojik olarak GTH tanısı alan 134 hasta geriye dönük olarak çalışmaya alındı. Bu hastaların başvuru şikâyetleri, demografik verileri, laboratuvar tahlilleri, uygulanan tedaviler, eşlik eden diğer hastalıkların varlığı, GTH histolojik alt tipi, transfüzyon ve kemoterapi ihtiyaçları değerlendirildi. Parsiyel ve komplet mol hidatiform gebelikler birbirleriyle karşılaştırıldı. Bulgular: Hastalarda ortalama yaş 29,9±7,49 olarak bulundu. Histopatolojik sonuçlara göre parsiyel mol tanılı 91 hasta (%67,9), komplet mol tanılı 37 hasta (%27,6) bulundu. İnvaziv mol bir hastada (%0,7), koryokarsinom bir hastada (%0,7), plasental yerleşimli trofoblastik tümör (PSTT) bir hastada (%0.7) tespit edildi. GTH tanısı ortalama 8. haftada konuldu. GTH hastalarında en çok A Rh (+) kan grubu, en az B Rh (-) ve AB Rh (-) kan grupları izlendi. Sonuç: Bölgesel olarak farklı insidans gösteren GTH’de erken teşhis ve uygun takip-tedavinin yapılması bu hastalıkla ilişkili morbidite ve mortalitenin önlenmesinde önemli rol oynamaktadır.

Anahtar Kelimeler:

Gestasyonel trofoblastik hastalık, β-hCG, İnvaziv Mol, Mol Hidatiform

Evaluation of Cases Diagnosed with Gestational Trophoblastic Disease

Objective: The aim of our study is to discuss the incidence, demographic characteristics, complications, follow-up and treatment approaches of our patients diagnosed with gestational trophoblastic disease (GTH) with current literature. Materials and Methods: 134 patients who were diagnosed with GTD histopathologically in our clinic between 2005 and 2020 were included in the study retrospectively. Application complaints, demographic data, laboratory tests, treatments, presence of other comorbidities, histological subtype of GTD, transfusion and chemotherapy needs of these patients were evaluated. Partial and complete molar hydatiform pregnancies were compared with each other. Results: The mean age of the patients was 29.9±7.49 years. According to the histopathological results, 91 patients (67.9%) with partial mole and 37 (27.6%) patients with complete mole were found. Invasive mole was detected in one patient (0.7%), choriocarcinoma in one patient (0.7%), and placental trophoblastic tumor (PSTT) in one patient (0.7%). The diagnosis of GTD was made at an average of 8 weeks. In GTD patients, A Rh (+) blood group was the most, B Rh (-) and AB Rh (-) blood groups were the least. Conclusion: Early diagnosis and appropriate follow-up-treatment in GTD, which has a regionally different incidence, play an important role in preventing the morbidity and mortality associated with this disease.

Keywords:

Gestational trophoblastic disease, β-hCG, Hydatiform mole, Invasive mole,

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