POLAROGRAPHIC DETERMINATION OF LORNOXICAM IN PHARMACEUTICAL FORMULATIONS - FARMASÖTİK FORMÜLLERDEKİ LORNOKSİKAMIN POLAROGRAFİK TAYİNİ

POLAROGRAPHIC DETERMINATION OF LORNOXICAM IN PHARMACEUTICAL FORMULATIONSA simple, precise, fast and low-cost differential pulse polarographic (DPP) method fordetermination of lornoxicam in pharmaceutical formulations has been proposed. The results have beencompared with those of high performance liquid chromatography (HPLC) method. Mean values andstandard deviations calculated by ten determinations were 8.10 ± 0.12 mg for DPP and six determinationswere 8.02 ± 0.08 mg for the HPLC method. The statistical evaluations indicated that there was no significantdifference between the mean values and precessions of the two methods at 95% confidence level (t=2.64,F=2.25)FARMASÖTİK FORMÜLLERDEKİ LORNOKSİKAMIN POLAROGRAFİK TAYİNİBu çalısmada farmasötik formüllerde bulunan lornoksikamı tayin etmek için basit, duyarlı, hızlı veucuz bir yöntem önerilmistir. Bu yöntemle elde edilen sonuçlar yüksek performanslı sıvı kromatografisi(HPLC) yöntemi ile elde edilenlerle karsılastırılmıstır. Tabletlerdeki lornoksikam miktarı için ortalamadegerler ve standart sapmalar diferansiyel puls polarografik (DPP) yöntem için on tayinle 8.10 ± 0.12 mg,HPLC için altı tayinle 8.02 ± 0.08 mg olarak hesaplanmıstır. statistiksel degerlendirme, % 95 güvenirlikdüzeyinde bu iki yöntem arasında ortalama degerler ve duyarlık bakımından önemli bir fark olmadıgınıgöstermistir (t=2.64, F=2.25).

Anahtar Kelimeler:

Lornoksikam, Antienflamatuar, Polarografi

Polarographic Determination of Lornoxicam in Pharmaceutical Formulations

Keywords:

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