Serum Melatonin Levels in Patients with Sudden Sensorineural Hearing Loss

Objective: This study aimed to investigate the serum melatonin levels of patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Methods: This study enrolled 22 patients with ISSNHL and 22 asymptomatic healthy volunteers. The subjects underwent pure tone audiometry and serum melatonin levels were measured. Results: The patient group was composed of 12 women (mean age, 46.41±7.8) and 10 men (mean age, 48±6.46), and the control group was composed of 12 women (mean age, 40.25±5.28) and 10 men (mean age, 38.4±27.08). The serum melatonin levels were significantly lower in the patient group than in the control group (p≤0.001). A statistically significant strong negative correlation was found between serum melatonin level and severity of hearing loss (r=−0.644; p=0.001). Conclusion: Serum melatonin levels of patients with ISSNHL were lower than controls. A statistically significant strong negative correlation was found between serum melatonin level and the severity of hearing loss.

Ani Sensörinöral İşitme Kaybında Serum Melatonin Düzeyleri

Amaç: Bu çalışmanın amacı, idiyopatik ani sensörinöral işitme kaybı (İASİK) olan hastaların serum melatonin düzeylerini ortaya koymaktır. Yöntemler: İASİK olan 22 hasta ve 22 asemptomatik sağlıklı gönüllü çalışmaya dahil edildi. Katılımcılara saf ses odyometrisi uygulandı ve katılımcıların serum melatonin seviyeleri ölçüldü. Bulgular: Hasta grubunda 12 kadın [ortalama (ort.) yaş: 46,41±7,8] ve 10 erkek (ort. yaş: 48±6,46) vardı. Kontrol grubunda 12 kadın (ort. yaş: 40,25±5,28) ve 10 erkek (ort. yaş: 38,4±27,08) vardı. Serum melatonin düzeylerinin hasta grubunda kontrol grubuna göre anlamlı derecede düşük olduğu saptandı (p≤0,001). Serum melatonin seviyesi ile işitme kaybının şiddeti arasında istatistiksel olarak anlamlı güçlü negatif bir korelasyon vardı (r=-0,644; p=0,001). Sonuç: İASİK olan hastaların serum melatonin düzeyleri kontrol grubundan daha düşüktü. Serum melatonin seviyesi ile işitme kaybının şiddeti arasında istatistiksel olarak anlamlı güçlü negatif bir korelasyon vardı.

Kaynakça

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