Comparison of the Role of Endocan With Other Laboratory Tests in Diagnosis of Acute and Perforated Appendicitis in Children

Objective: In this study, we aimed to determine the role and efficacy of endocan and other routine laboratory tests to diagnose of acute appendicitis (AA) and determining perforation. Methods: One hundred patients under the age of 16 who were diagnosed appendicitis were included the study. The patients were divided into two groups as acute and perforated appendicitis. Complete blood count, C-reactive protein (CRP) and endocan values were evaluated on admission and on postoperative 48th hour. Obtained endocan samples and concomitantly obtained CRP, white blood cell (WBC) count, and neutrophil lymphocyte ratio (NLR) parameters were compared preoperatively and postoperatively in terms of perforated and non-perforated (acute) appendicitis. Results: In this study, 74.2% of the patients were acute and 25.8% were perforated. In both groups, more than half of the patients had an endocan value of less than 50 ng/mL. Specificity and sensitivity of endocan were lower than other inflammation markers to determine AA and perforation. It was shown that the combined evaluation of CRP and NLR values of

Endokanın Çocuklardaki Akut ve Perfore Apandisit Tanısındaki Rolünün Diğer Laboratuvar Testleri ile Kıyaslanması

Amaç: Bu çalışmada, endokan ve diğer rutin laboratuvar testlerinin akut apandisit (AA) tanısında ve perforasyonun belirlenmesindeki rolünü ve etkinliğini belirlemeyi amaçladık. Yöntemler: Çalışmamıza 16 yaşından küçük, apandisit tanısı konmuş 100 hasta dahil edildi. Hastalar akut ve perfore apandisit olarak iki gruba ayrıldı. Tam kan sayımı, C-reaktif protein (CRP) ve endokan değerleri başvuru sırasında ve ameliyat sonrası 48. saatte bakıldı. Elde edilen endokan örnekleri ve aynı zamanda alınan CRP, beyaz kan hücresi sayısı (WBC) ve nötrofil lenfosit oranı (NLR) parametreleri, preoperatif ve postoperatif olarak perfore ve perfore olmayan (akut) apandisit açısından karşılaştırıldı. Bulgular: Bu çalışmada hastaların %74,2’si akut, %25,8’i perfore apandisit tanısı aldı. Her iki grupta da hastaların yarısından fazlasında endokan değeri 50 ng/mL’den daha az olarak saptandı. AA ve perforasyonu belirlemek için endokanın özgüllüğü ve duyarlılığı diğer inflamasyon belirteçlerinden daha düşük bulundu. CRP

Kaynakça

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