Obez Çocuk ve Adölesanlarda Düzenli Süt Tüketimi ile İnsülin Direnci Arasındaki Ters İlişki

Amaç: Bu araştırmanın amacı, obez çocuk ve adölesanlarda düzenli süt tüketimi ile insülin direnci arasındaki ilişkiyi belirlemektir. Bireyler ve Yöntem: Araştırmaya 6-17 yaş aralığındaki 136 obez birey dahil edilmiştir. Süt tüketim sıklığı, besin tüketim sıklığı anketi ile değerlendirilmiş ve haftada beş defa ya da daha fazla tüketim "düzenli" olarak kabul edilmiştir. Ayrıca, potansiyel karıştırıcı etmen olabileceği düşünülen bireylerin fiziksel aktivite durumu ve günlük enerji alımı belirlenmiştir. İnsülin direncini değerlendirmek için, açlık glukoz ve insülin düzeyleri ile hesaplanan Homeostatik Model İnsülin Direnci Değerlendirmesi (HOMA-IR) skoru kullanılmıştır. Düzenli süt tüketimi ile insülin direnci arasındaki ilişki, potansiyel karıştırıcı etmenler için düzeltme yapılarak ikili lojistik regresyon analizi ile incelenmiştir. Bulgular: Yaş ortalaması 11.54±2.84 yıl olan katılımcıların %40.4'ü erkek ve %59.6'sı kızdır. Düzenli süt tüketen (>=5 kez/hafta) bireylerin açlık insülin düzeyinin ve HOMA-IR skorlarının, tüketmeyenlere göre daha düşük olduğu saptanmıştır (p0.05). Oluşturulan ikili lojistik regresyon modellerinde, süt tüketiminin insülin direncini negatif yönde ve istatistiksel açıdan önemli düzeyde etkilediği gösterilmiştir. Yaş, cinsiyet, fiziksel aktivite ve günlük enerji alımı gibi potansiyel karıştırıcı etmenler için düzeltme yapıldığında, düzenli süt tüketiminin obez çocuk ve adölesanlarda insülin direnci gelişme riskini %60.3 (%95 Güven Aralığı: 0.181-0.869) oranında azalttığı (p=0.021) belirlenmiştir. Sonuç: Bu araştırmadan elde edilen sonuçlar, obez çocuk ve adölesanlar tarafından düzenli süt tüketiminin düşük insülin direnci ile ilişkili olabileceğini göstermektedir

Inverse Association between Regular Milk Consumption and Insulin Resistance in Obese Children and Adolescents

Aim: The aim of this study is to determine the association between the regular milk consumption and insulin resistance in obese children and adolescents. Subjects and Methods: This research was carried out on 136 obese subjects aged 6-17 years. Frequency of milk consumption was assessed using a food frequency questionnaire and consumption five times or more per week was considered “regular”. In addition, the physical activity levels and daily energy intake of subjects, that thought to be potential confounding factors, were identified. To assess insulin resistance, the Homeostatic Model Assessment of IR (HOMA-IR) score, calculated from fasting glucose and insulin levels, was used. The association between regular milk consumption and insulin resistance was examined by binary logistic regression analysis with adjustment for potential confounding factors. Results: The 40.4% of participants, whose mean age were 11.54±2.84 years, were male and 59.6% were female. It was determined that fasting insulin levels and HOMA-IR scores of subjects who consumed regular milk (≥5 times/week) were lower than those who did not (p0.05). In the generated logistic regression models, it has been shown that milk consumption significantly affects insulin resistance in a negative and statistically significant manner. When adjusted for potential confounding factors such as age, gender, physical activity and daily energy intake, regular consumption of milk reduced the risk of developing insulin resistance in obese children and adolescents by 60.3% (95% Confidence Interval: 0.181-0.869) (p=0.021). Conclusion: The results of this study indicate that the regular milk consumption may be associated with lower insulin resistance among obese children and adolescents

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