Maternal Folik Asit Suplemantasyonunun Rat Yavrularında Doğum Ağırlığı ve Obezite Gelişimi Üzerine Etkilerinin Değerlendirilmesi

Amaç: Bu çalışmada gebelik boyunca farklı miktarlarda folik aside (FA) maruz bırakılan rat yavrularının doğum ağırlığı ile obezite gelişimi üzerine etkilerinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Wistar türü dişi ratların (n=18) gebe kalmaları sağlanmış ve randomize şekilde üç gruba ayrılmıştır. Gebelik döneminde her gruba FA içerikleri farklı üç ayrı beslenme protokolü (Kontrol grubu [KG]: 2 mg/kg folik asit, Deney 1 grubu [D1]: 5 mg/kg folik asit, Deney 2 grubu [D2]: 40 mg/kg folik asit) uygulanmıştır. Kontrol ve deney grubu yavruların doğum ağırlığına bakılmıştır. Laktasyon dönemi sonrasında her gruptan 12 yavru (6 dişi ve 6 erkek) olmak üzere toplamda 36 yavrunun haftalık vücut ağırlığı takibi yapılmıştır. Yedi ve on ikinci haftaların sonunda yavruların obezite durumu (Lee indeksi) değerlendirilmiştir. Çalışmaya toplamda 18 anne ve 36 yavru olmak üzere 54 rat dahil edilmiştir. Bulgular: En yüksek ortalama doğum ağırlığının, D2 grubundaki ratlardan doğan yavrularda olduğu belirlenmiştir (KG: 5.6±0.1 g; D1: 5.8±0.5 g; D2: 5.9±0.2 g; p

Evaluation of Effects of Maternal Folic Acid Supplementation on Birth Weight and Obesity Development in the Offspring of Rats

Aim: This study aimed to evaluate the effects of different amounts of maternal folic acid (FA) supplementation on birth weight and obesity development in the offspring of rats. Material and Method: Wistar female rats (n=18) were mated and randomly divided into three groups. Three different feeding protocols were administered to each group during pregnancy (Control group [CG]: 2 mg/kg folic acid, Experimental group 1 [E1]: 5 mg/kg folic acid, Experimental group 2 [E2]: 40 mg/kg folic acid). Birth weights of pups in each group were recorded. Body weights of total 36 pups including 12 pups (6 females and 6 males) from each group were monitored weekly after lactation period. Pups were evaluated for obesity (Lee index) at the end of the 7th and 12th weeks. In total, 54 rats (18 mother rats and 36 pups) were included. Results: The highest mean birth weight was found in E2 group pups (CG: 5.6±0.1 g; E1: 5.8±0.5 g; E2:5.9±0.2 g, p

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