Fatma ILGAZ, Perihan ARSLAN, Şuayip YALÇIN

Kemoterapinin Kolon Kanserli Hastaların Beslenme Durumlarına Etkisi

Amaç: Bu araştırma, kemoterapi (KT) süresince kolon kanserli hastaların beslenme durumlarında oluşan değişimleri saptamak amacıyla planlanmıştır. Bireyler ve Yöntem: Hacettepe Üniversitesi Onkoloji Hastanesi'ne başvuran, yeni tanı almış, KT alması planlanan kolon kanserli hastalar çalışmaya dahil edilmiştir. Tüm hastalar 6 kür tedavi boyunca izlenmiş ve her hastadan KT öncesi, sırası (3. kür) ve sonu (6. kür) olmak üzere toplam üç aşamada veri toplanmıştır. Kemoterapi öncesi dönemde hastalara bir anket formu uygulanmış, ayrıca KT öncesi, sırası ve sonundaki dönemlerde tüm bireylerin besin tüketim kayıtları (3 gün), fiziksel aktivite kayıtları (1 gün) ve antropometrik ölçümleri alınmış ve vücut bileşimleri analiz edilmiştir. Bulgular: Araştırmaya yaş ortalaması 61.3±8.17 yıl olan 17 erkek (%58.6) ve 12 kadın (%41.4) olmak üzere toplam 29 kişi dahil edilmiştir. Tedavi süresince en sık görülen yan etkilerin iştahsızlık, halsizlik, ağız kuruluğu ile tat ve koku almada değişiklik olduğu saptanmıştır. Hastaların ortalama enerji alımlarının KT öncesi döneme göre KT sırasında azaldığı, KT sonunda ise arttığı belirlenmiştir (p

Effects of Chemotherapy on Nutritional Status of Colon Cancer Patients

Aim: This study was planned to determine the changes in nutritional status of colon cancer patients during chemotherapy (CT). Subjects and Method: Newly diagnosed colon cancer patients who were admitted to Hacettepe University Oncology Hospital to receive CT were evaluated at three phases: before, during (3rd cycle) and end (6th cycle) of CT. A questionnaire was performed before treatment, where dietary records (3 consecutive days) and physical activity records (1 day) were taken,and also anthropometric measurements and body compositions were analyzed before, during and at the end of CT. Results: A total of 29 colon cancer patients (mean age: 61.3±8.17 years, 58.6% male) were included. Appetite loss, fatigue, dry mouth and taste and odor abnormalities were the most frequent symptoms during the treatment. Mean energy intake decreased during CT and increased at the end of CT compared to baseline (p<0.05). There was no significant difference in energy balance, anthropometric measurements and body composition of male subjects between three phases. However, body weight, BMI and body fat of female subjects increased significantly between 3rd and 6th cycles as a result of an increased energy intake and decreased energy expenditure. Physical activity levels were also declined during and at the end of CT compared to baseline. Conclusion: Chemotherapy has a great impact on energy intake, energy expenditure, activity level, and body weight and body composition of colon cancer patients. In particular, the increase in body weight and body fat occurring in female patients during treatment may influence the prognosis of the disease and the risk of mortality.

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