Çölyak Olmayan Gluten Duyarlılığı

Çölyak olmayan gluten duyarlılığı, son birkaç yılda, bilim topluluğu tarafından büyük ilgi görmektedir. Çölyak hastalığı veya buğday alerjisinin tanı kriterlerine uymayan hastaların gluteni diyetten çıkarması ile yanıt veren gastrointestinal veya ekstraintestinal semptomlarla karakterizedir. İrritabl Bağırsak Sendromu ile benzer belirgin belirtiler vermektedir. Prevalansın çölyak hastalığından biraz daha yaygın olduğu belirtilmiştir. Çoğunlukla yetişkinlerde, özellikle 30-50 yaş grubunda ve ağırlıklı kadın cinsiyetinde sık görülmekle birlikte pediatrik hastalarda da bildirilmiştir. Çölyak olmayan gluten duyarlılığı hastalarına glutensiz diyet tedavisi tavsiye edilmektedir ancak hastaları etkileyen gluten miktarı bireylere göre farklılık göstermektedir. Hastaların büyük bir kısmında glutensiz diyet tedavisi sonrasında semptomlar ortadan kalkmaktadır. Bu makalede çölyak olmayan gluten duyarlılığı konusundaki güncel bilgiler gözden geçirilmiş, çölyak hastalığı ile farklılıklarına değinilmiş ve bu yeni durumun patofizyolojisi konusunda olası mekanizmalardan bahsedilmiştir.

Non-Celiac Gluten Sensitivity

In the last few years, non-celiac gluten sensitivity has received great interest from the scientific community. The disease is characterized by gastrointestinal or extraintestinal symptoms that respond with the extraction of gluten from the diet of patients not diagnosed with celiac disease or wheat allergy. It gives similar symptoms like irritable bowel syndrome. Prevalence is reported to be slightly more common than celiac disease. It has been reported mostly in adults, especially in the 30-50 age group and female gender, but has also been reported in pediatric patients. Gluten free diet therapy is recommended for patients with non celiac gluten sensitivity but the amount of gluten that affects patients varies according to individuals. Symptoms disappear after a gluten free diet. In this article, current information about non-celiac gluten sensitivity and the differences from celiac disease are reviewed. Possible mechanisms for the pathophysiology of this new condition are discussed.

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