Özlem AYDIN BERKTAŞ, Fadime ATALAY DUMLU

Sıçanlarda İndometazin ile İndüklenen Mide Ülseri Üzerine Badem ve Elma Yağının Koruyucu Etkileri

Amaç: Günümüzde geleneksel ve alternatif tedavide bitkisel yağların kullanımı önem kazanmıştır. Özellikle doymamış yağ asit bileşimi fazla olan yağların tercih edilmesi birçok araştırmaya konu olmasına neden olmuştur. Gereç ve Yöntem: Bu araştırmada da özellikle meyve ve kuruyemiş olarak kullanılan badem ve elma yağının koruyucu etkileri bir antienflamatuvar ilaç olan indometazin (İND) indüklemeli ülser modelinde belirlenmiştir. Deney grupları 0.5 ve 1 ml/kg dozda olacak şekilde badem ve elma yağı, pozitif kontrol famotidin grubu, negatif grup olarak da indometazin ve en son grup sağlıklı olacak şekilde belirlenmiştir. 24 saatlik açlık sonunda deney hayvanlarının mide dokularında biyokimyasal parametreler antiülser etkiyi ifade etmiştir. Bulgular: Uygulanan indometazin ile artan lipid peroksidasyon (LPO) seviyeleri, katalaz (KAT), glutatyon redüktaz (GR) ve miyeloperoksidaz (MPx) enzim aktiviteleri önemli oranda yağlar tarafından azaltılmıştır. Aynı zamanda uygulanan indometazin ile azalan glutatyon (GSH) seviyelerini de badem ve elma yağı önemli oranda arttırmıştır. Sonuç: Bu veriler doğrultusunda badem ve elma yağının her iki dozu da ülsere karşı önemli oranda koruma sağlamıştır.

The protective Effects of Almond and Apple Oil on Indomethacin-Induced Stomach Ulcer in Rats

Objective: Today, the use of vegetable oils in traditional and alternative therapy has gained importance. Especially the preference of oils with high unsaturated fatty acid composition has caused many researches. Materials and Methods: In this study, the protective effects of almond and apple oil, which are especially used as fruits and nuts, were determined in an ulcer model induced by an anti-inflammatory drug, indomethacin (IND). The experimental groups were determined to be 0.5 and 1 ml/kg doses of almond and apple oil, the positive control famotidine group, indomethacin as the negative group, and the last group to be healthy. At the end of the 24-hour fasting, the biochemical parameters expressed the antiulcer effect in the stomach tissues of the experimental animals. Results: Lipid peroxidatione (LPO) levels increased with the applied indomethacin, catalase (CAT), glutathione reductase (GR) and myeloperoxidase (MPx) enzyme activities were significantly reduced by oils. At the same time, the decreased glutathione (GSH) levels with indomethacin applied significantly increased the levels of almond and apple oil. Conclusion: In line with these data, both doses of almond and apple oil provided significant protection against ulcers.

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