Frequencies of Allergic Diseases Among Children with Autism Spectrum Disorders

Objective: Allergic diseases and autism spectrum disorders (ASD) affect millions of children worldwide and the frequencies of these diseases are increasing. Although some genetic and environmental factors have been implicated, the exact reasons of this increase have not been determined yet. In this study, we aimed to investigate the frequencies of allergic diseases among children with ASD. Materials and Methods: A questionnaire containing 23 questions related to asthma, allergic rhinitis, atopic dermatitis and food allergy adapted from the International Study of Asthma and Allergies in Childhood (ISAAC) was used and the questionnaires were filled out by the parents of children with ASD and controls. Results: The study and control groups comprised 59 and 50 children respectively. Allergic rhinitis was diagnosed in 12%, atopic dermatitis in 10.1%, food allergy in 8.4% and asthma in 6.8% of the children with ASD; and 16%, 6%, 8% and 10.0% respectively in the control group. Conclusion: These results suggest that frequency of allergic diseases among children with ASD are not different than controls.

Kaynakça

1. Björkstén B, Clayton T, Ellwood P, Stewart A, Strachan D; ISAAC Phase III Study Group. Worldwide time trends for symptoms of rhinitis and conjunctivitis: Phase III of the International Study of Asthma and Allergies in Childhood. Pediatr Allergy Immunol 2008;19:110-24.

2. Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators, Centers for Disease Control and Prevention (CDC). Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveill Summ 2014;63 (2):1-21.

3. Gardener H, Spiegelman D, Buka SL. Perinatal and neonatal risk factors for autism: A comprehensive meta-analysis. Pediatrics 2011;128:344-55.

4. Schwartz DA. Gene-environment interactions and airway disease in children. Pediatrics 2009; 123 Suppl 3:S151-9.

5. Chen MH, Su TP, Chen YS, Hsu JW, Huang KL, Chang WH, et al. Is atopy in early childhood a risk factor for ADHD and ASD? a longitudinal study. J Psychosom Res 2014;77:316-21.

6. ISAAC Steering Committee. Worldwide variations in the prevalence of asthma symptoms: The International Study of Asthma and Allergies in Childhood (ISAAC). Eur Respir J 1998;12:315-35.

7. Muskens JB, Velders FP, Staal WG. Medical comorbidities in children and adolescents with autism spectrum disorders and attention deficit hyperactivity disorders: A systematic review. Eur Child Adolesc Psychiatry 2017;26:1093-103.

8. Cetinkaya F, Gelen SA, Kervancioglu E, Oral E. Prevalence of asthma and other Allergic diseases in children born after in vitro fertilisation. Allergol Immunopathol (Madr) 2009;37:11-3.

9. Boulet LP. Obesity and atopy. Clin Exp Allergy 2015;45:75-86.

10. Perrin JM, Bloom SR, Gortmaker SL. The increase of childhood chronic conditions in the United States. JAMA 2007;297:2755-9.

11. Xue Ming, Brimacombe M, Chaaban J, Zimmerman-Bier B, Wagner GC. Autism spectrum disorders: Concurrent clinical disorders. J Child Neurol 2008;23(1):6-13.

12. Abrahams BS, Geschwind DH. Nat Advances in autism genetics: On the threshold of a new neurobiology Rev Genet 2008;9:341- 55.

13. Theoharides TC. Is a subtype of autism an allergy of the brain? Clin Ther 2013;35:584-91.

14. Lyall K, Van de Water J, Ashwood P, Hertz-Picciotto I. Asthma and allergies in children with autism spectrum disorders: Results from the CHARGE study. Autism Res 2015;8:567-74.

15. Gurney JG, McPheeters ML, Davis MM. Parental report of health conditions and health care use among children with and without autism: National Survey of Children’s Health. Arch Pediatr Adolesc Med 2006;160:825-30.

16. Magalhães ES, Pinto-Mariz F, Bastos-Pinto S, Pontes AT, Prado EA, deAzevedo LC. Immune allergic response in Asperger syndrome. J Neuroimmunol 2009;216:108-12.

17. Jyonouchi H, Geng L, Cushing-Ruby A, Quraishi H. Impact of innate immunity in a subset of children with autism spectrum disorders: A case control study. J Neuroinflammation 2008; 21;5:52-66.

18. Bakkaloglu B, Anlar B, Anlar FY, Oktem F, Pehlivantürk B, Unal F, et al. Atopic features in early childhood autism. Eur J Paediatr Neurol 2008;12:476-9.

19. Zerbo O, Leong A, Barcellos L, Bernal P, Fireman B, Croen LA. Immune mediated conditions in autism spectrum disorders. Brain Behav Immun 2015;46:232-6.

20. Saraçlar Y, Sekerel BE, Kalayci O, Cetinkaya F, Adalioğlu G, Tuncer A, et al. Prevalence of asthma symptoms in school children in Ankara, Turkey. Respir Med 1998;92:203-7.

Kaynak Göster